Detailed information of TA system TA212193

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 950943..951585
• Replicon: chromosome
• Accession: NZ_CP080576
• Organism: Acinetobacter lwoffii strain VS15

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: ABVS_RS04615
• Protein ID: WP_222112282.1
• Coordinates: 950943..951335 (-)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: N8Q7K6
• Locus tag: ABVS_RS04620
• Protein ID: WP_004645065.1
• Coordinates: 951328..951585 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ABVS_RS04600 (ABVS_0962)	946253..948535	-	2283	WP_222112279.1	TRAP transporter large permease subunit	-
ABVS_RS04605 (ABVS_0963)	948733..949305	-	573	WP_222112280.1	rhombosortase	-
ABVS_RS04610 (ABVS_0964)	949373..950413	-	1041	WP_222112281.1	hypothetical protein	-
ABVS_RS04615 (ABVS_0965)	950943..951335	-	393	WP_222112282.1	hypothetical protein	Toxin
ABVS_RS04620 (ABVS_0966)	951328..951585	-	258	WP_004645065.1	succinate dehydrogenase assembly factor 2	Antitoxin
ABVS_RS04625 (ABVS_0967)	951769..952941	+	1173	WP_222112283.1	acyl-CoA dehydrogenase family protein	-
ABVS_RS04630 (ABVS_0968)	953004..954494	-	1491	WP_222112284.1	NAD(P)/FAD-dependent oxidoreductase	-
ABVS_RS04635 (ABVS_0969)	954712..955077	-	366	WP_004281488.1	50S ribosomal protein L17	-
ABVS_RS04640 (ABVS_0970)	955096..956103	-	1008	WP_004281489.1	DNA-directed RNA polymerase subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-80)

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 15495.68 Da
• Isoelectric Point: 9.8125

>T212193 WP_222112282.1 NZ_CP080576:c951335-950943 [Acinetobacter lwoffii]
MDNRCFKLKRSLCALAFQLFIFALLMYLLYQLLPIALWAVCAVIGLLIYQLFYRKTPQIEQFEYLDGREWSLTAKARPTR
RVCISHVIDHQAYIVVYFQHAKARPLLIWCDQLPFKQWKSLKLLTKLIEL

Nucleotide

• Length: 393 bp

>T212193 NZ_CP106997:1800483-1800737 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10366.85 Da
• Isoelectric Point: 4.4809

>AT212193 WP_004645065.1 NZ_CP080576:c951585-951328 [Acinetobacter lwoffii]
MTDDISLEERKVIYRARRGLKELDVYFDPYVKNYYLNAEPFEKQMFAELVEQEDPDLLDWFMEVSEPPRPELKDFIKKLK
FYVHG

Nucleotide

• Length: 258 bp

>AT212193 NZ_CP106997:1800235-1800486 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Structures

Antitoxin

• AlphaFold DB: N8Q7K6