Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2248587..2249101 Replicon chromosome
Accession NZ_CP080566
Organism Staphylococcus aureus strain HL20835 isolate HL20835

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag JMO16_RS11365 Protein ID WP_000581792.1
Coordinates 2248587..2248796 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag JMO16_RS11370 Protein ID WP_000138932.1
Coordinates 2248808..2249101 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMO16_RS11345 (2244095) 2244095..2245453 - 1359 WP_000611464.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
JMO16_RS11350 (2245468) 2245468..2246538 - 1071 WP_042109557.1 D-alanine--D-alanine ligase -
JMO16_RS11355 (2246856) 2246856..2248058 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
JMO16_RS11360 (2248322) 2248322..2248459 - 138 WP_000828354.1 Lmo0850 family protein -
JMO16_RS11365 (2248587) 2248587..2248796 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
JMO16_RS11370 (2248808) 2248808..2249101 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
JMO16_RS11375 (2249267) 2249267..2250751 + 1485 WP_000571549.1 cardiolipin synthase -
JMO16_RS11380 (2250779) 2250779..2251426 + 648 WP_001187630.1 HD domain-containing protein -
JMO16_RS11385 (2252339) 2252339..2253211 - 873 WP_000725802.1 membrane protein insertase YidC -
JMO16_RS11390 (2253297) 2253297..2253938 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T212184 WP_000581792.1 NZ_CP080566:c2248796-2248587 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T212184 NZ_CP106997:183125-183232 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT212184 WP_000138932.1 NZ_CP080566:c2249101-2248808 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT212184 NZ_CP106997:c183077-183011 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References