Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /HTH_XRE(antitoxin) |
| Location | 1107960..1108760 | Replicon | chromosome |
| Accession | NZ_CP080566 | ||
| Organism | Staphylococcus aureus strain HL20835 isolate HL20835 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A0C6E139 |
| Locus tag | JMO16_RS05420 | Protein ID | WP_031767738.1 |
| Coordinates | 1107960..1108424 (-) | Length | 155 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A0C2LD36 |
| Locus tag | JMO16_RS05425 | Protein ID | WP_001260487.1 |
| Coordinates | 1108437..1108760 (-) | Length | 108 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JMO16_RS05395 (1103463) | 1103463..1104602 | - | 1140 | WP_000843611.1 | nucleotidyltransferase | - |
| JMO16_RS05400 (1104729) | 1104729..1105286 | + | 558 | WP_000872158.1 | DUF177 domain-containing protein | - |
| JMO16_RS05405 (1105366) | 1105366..1105539 | + | 174 | WP_000290472.1 | 50S ribosomal protein L32 | - |
| JMO16_RS05410 (1105656) | 1105656..1107041 | - | 1386 | WP_000861313.1 | recombinase family protein | - |
| JMO16_RS05415 (1107248) | 1107248..1107928 | - | 681 | WP_000392109.1 | type II toxin-antitoxin system PemK/MazF family toxin | - |
| JMO16_RS05420 (1107960) | 1107960..1108424 | - | 465 | WP_031767738.1 | toxin | Toxin |
| JMO16_RS05425 (1108437) | 1108437..1108760 | - | 324 | WP_001260487.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| JMO16_RS05430 (1108924) | 1108924..1109172 | + | 249 | WP_000272859.1 | helix-turn-helix transcriptional regulator | - |
| JMO16_RS05435 (1109186) | 1109186..1109629 | + | 444 | WP_000435360.1 | hypothetical protein | - |
| JMO16_RS05440 (1109644) | 1109644..1110432 | + | 789 | WP_001148566.1 | phage antirepressor KilAC domain-containing protein | - |
| JMO16_RS05445 (1110449) | 1110449..1110643 | + | 195 | WP_000390105.1 | hypothetical protein | - |
| JMO16_RS05450 (1110696) | 1110696..1110872 | + | 177 | WP_001094935.1 | hypothetical protein | - |
| JMO16_RS05455 (1110847) | 1110847..1111077 | - | 231 | WP_220360727.1 | hypothetical protein | - |
| JMO16_RS05460 (1111127) | 1111127..1111264 | + | 138 | WP_000230552.1 | hypothetical protein | - |
| JMO16_RS05465 (1111257) | 1111257..1111418 | + | 162 | WP_220360728.1 | DUF1270 family protein | - |
| JMO16_RS05470 (1111512) | 1111512..1111772 | + | 261 | WP_000291075.1 | DUF1108 family protein | - |
| JMO16_RS05475 (1111787) | 1111787..1112266 | + | 480 | WP_000002510.1 | siphovirus Gp157 family protein | - |
| JMO16_RS05480 (1112266) | 1112266..1112904 | + | 639 | WP_001043065.1 | ERF family protein | - |
| JMO16_RS05485 (1112904) | 1112904..1113329 | + | 426 | WP_000934780.1 | single-stranded DNA-binding protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1105656..1146778 | 41122 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 155 a.a. Molecular weight: 18142.45 Da Isoelectric Point: 4.6815
>T212171 WP_031767738.1 NZ_CP080566:c1108424-1107960 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKLHHID
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKLHHID
Download Length: 465 bp
>T212171 NZ_CP106996:1967178-1967281 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT
Antitoxin
Download Length: 108 a.a. Molecular weight: 12431.09 Da Isoelectric Point: 9.3811
>AT212171 WP_001260487.1 NZ_CP080566:c1108760-1108437 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK
Download Length: 324 bp
>AT212171 NZ_CP106996:c1967319-1967048 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0C6E139 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0C2LD36 |