Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsaAT/- |
| Location | 849581..850058 | Replicon | chromosome |
| Accession | NZ_CP080566 | ||
| Organism | Staphylococcus aureus strain HL20835 isolate HL20835 | ||
Toxin (Protein)
| Gene name | TsaT | Uniprot ID | T1Y7S2 |
| Locus tag | JMO16_RS04075 | Protein ID | WP_000052076.1 |
| Coordinates | 849581..849769 (-) | Length | 63 a.a. |
Antitoxin (Protein)
| Gene name | TsaA | Uniprot ID | T1Y6P8 |
| Locus tag | JMO16_RS04080 | Protein ID | WP_001059690.1 |
| Coordinates | 849798..850058 (-) | Length | 87 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JMO16_RS04045 (845575) | 845575..846096 | + | 522 | WP_000824482.1 | hypothetical protein | - |
| JMO16_RS04050 (846437) | 846437..847123 | + | 687 | WP_000141557.1 | thermonuclease family protein | - |
| JMO16_RS04055 (847480) | 847480..847680 | + | 201 | WP_001059082.1 | cold-shock protein | - |
| JMO16_RS04060 (848172) | 848172..848390 | - | 219 | WP_000005886.1 | hypothetical protein | - |
| JMO16_RS04065 (848452) | 848452..848736 | - | 285 | WP_001004399.1 | hypothetical protein | - |
| JMO16_RS04070 (848824) | 848824..849393 | - | 570 | WP_001106654.1 | lipoprotein N-acylation protein LnsA | - |
| JMO16_RS04075 (849581) | 849581..849769 | - | 189 | WP_000052076.1 | hypothetical protein | Toxin |
| JMO16_RS04080 (849798) | 849798..850058 | - | 261 | WP_001059690.1 | hypothetical protein | Antitoxin |
| JMO16_RS04085 (850399) | 850399..850602 | + | 204 | WP_000145163.1 | sterile alpha motif-like domain-containing protein | - |
| JMO16_RS04090 (850599) | 850599..850835 | - | 237 | WP_000349581.1 | hypothetical protein | - |
| JMO16_RS04095 (851060) | 851060..851641 | + | 582 | WP_001140693.1 | histidine phosphatase family protein | - |
| JMO16_RS04100 (851714) | 851714..852331 | - | 618 | WP_063663419.1 | LysE/ArgO family amino acid transporter | - |
| JMO16_RS04105 (852486) | 852486..852980 | - | 495 | WP_000569884.1 | GNAT family N-acetyltransferase | - |
| JMO16_RS04110 (853379) | 853379..853801 | - | 423 | WP_000974460.1 | organic hydroperoxide resistance protein | - |
| JMO16_RS04115 (853949) | 853949..854665 | + | 717 | WP_000150011.1 | type I 3-dehydroquinate dehydratase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7142.82 Da Isoelectric Point: 9.9971
>T212170 WP_000052076.1 NZ_CP080566:c849769-849581 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
Download Length: 189 bp
>T212170 NZ_CP106996:c1812379-1812005 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
Antitoxin
Download Length: 87 a.a. Molecular weight: 9940.09 Da Isoelectric Point: 4.0624
>AT212170 WP_001059690.1 NZ_CP080566:c850058-849798 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
Download Length: 261 bp
>AT212170 NZ_CP106996:c1812836-1812468 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0VP18 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0VN56 |