Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 821663..822192 Replicon chromosome
Accession NZ_CP080566
Organism Staphylococcus aureus strain HL20835 isolate HL20835

Toxin (Protein)


Gene name TscT Uniprot ID K7ZRX2
Locus tag JMO16_RS03915 Protein ID WP_001103933.1
Coordinates 821875..822192 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID A0A6B0BJC0
Locus tag JMO16_RS03910 Protein ID WP_001058487.1
Coordinates 821663..821872 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMO16_RS03875 (818114) 818114..818578 + 465 WP_001085183.1 SsrA-binding protein SmpB -
JMO16_RS03885 (819141) 819141..820247 - 1107 WP_000121223.1 tyrosine-type recombinase/integrase -
JMO16_RS03890 (820253) 820253..820870 - 618 WP_223200480.1 helix-turn-helix transcriptional regulator -
JMO16_RS03895 (821058) 821058..821264 + 207 WP_001060953.1 hypothetical protein -
JMO16_RS03900 (821300) 821300..821527 + 228 WP_000164237.1 helix-turn-helix transcriptional regulator -
JMO16_RS03905 (821524) 821524..821670 + 147 WP_000784893.1 hypothetical protein -
JMO16_RS03910 (821663) 821663..821872 + 210 WP_001058487.1 hypothetical protein Antitoxin
JMO16_RS03915 (821875) 821875..822192 + 318 WP_001103933.1 DUF1474 family protein Toxin
JMO16_RS03920 (822259) 822259..823128 + 870 WP_001002695.1 primase alpha helix C-terminal domain-containing protein -
JMO16_RS03925 (823145) 823145..824614 + 1470 WP_001668899.1 virulence-associated E family protein -
JMO16_RS03930 (824900) 824900..825262 + 363 WP_001039169.1 hypothetical protein -
JMO16_RS03935 (825264) 825264..825548 + 285 WP_000998179.1 hypothetical protein -
JMO16_RS03940 (825545) 825545..826186 + 642 WP_063663413.1 pathogenicity island protein -
JMO16_RS03945 (826636) 826636..826977 + 342 WP_001190615.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 815720..830955 15235


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-98)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12511.13 Da        Isoelectric Point: 4.6364

>T212169 WP_001103933.1 NZ_CP080566:821875-822192 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKEKINDVAIKHGWFVEDKFVKNELETKQEHINFSASYLEHRIQNEHTVELLQVYLKEFGELIQKF
HEIEKASSENFGEESDDAKKLKITE

Download         Length: 318 bp

>T212169 NZ_CP106996:1800483-1800737 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8228.24 Da        Isoelectric Point: 4.1682

>AT212169 WP_001058487.1 NZ_CP080566:821663-821872 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSIMNNFESYEHTEYVDGIEVVSEISPEKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT212169 NZ_CP106996:1800235-1800486 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K7ZRX2

Antitoxin

Source ID Structure
AlphaFold DB A0A6B0BJC0

References