Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2101493..2102007 Replicon chromosome
Accession NZ_CP080564
Organism Staphylococcus aureus strain HL16278

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag JMO07_RS10285 Protein ID WP_000581792.1
Coordinates 2101493..2101702 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag JMO07_RS10290 Protein ID WP_000138932.1
Coordinates 2101714..2102007 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMO07_RS10265 (2097001) 2097001..2098359 - 1359 WP_000611470.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
JMO07_RS10270 (2098374) 2098374..2099444 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
JMO07_RS10275 (2099762) 2099762..2100964 + 1203 WP_020978293.1 FtsW/RodA/SpoVE family cell cycle protein -
JMO07_RS10280 (2101228) 2101228..2101365 - 138 WP_000828354.1 Lmo0850 family protein -
JMO07_RS10285 (2101493) 2101493..2101702 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
JMO07_RS10290 (2101714) 2101714..2102007 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
JMO07_RS10295 (2102173) 2102173..2103657 + 1485 WP_000571549.1 cardiolipin synthase -
JMO07_RS10300 (2103685) 2103685..2104332 + 648 WP_001187630.1 HD domain-containing protein -
JMO07_RS10305 (2104804) 2104804..2105676 - 873 WP_000725802.1 membrane protein insertase YidC -
JMO07_RS10310 (2105762) 2105762..2106403 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T212162 WP_000581792.1 NZ_CP080564:c2101702-2101493 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T212162 NZ_CP106996:648758-649072 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT212162 WP_000138932.1 NZ_CP080564:c2102007-2101714 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT212162 NZ_CP106996:649069-649485 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References