Detailed information of TA system TA021216

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YefM
• Location: 1524362..1524890
• Replicon: chromosome
• Accession: NC_007204
• Organism: Psychrobacter arcticus 273-4

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q4FS92
• Locus tag: PSYC_RS06570
• Protein ID: WP_011280538.1
• Coordinates: 1524603..1524890 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q4FS93
• Locus tag: PSYC_RS06565
• Protein ID: WP_011280537.1
• Coordinates: 1524362..1524613 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PSYC_RS06550	1519684..1519995	+	312	WP_041758022.1	DUF493 domain-containing protein	-
PSYC_RS06555	1520712..1522988	+	2277	WP_011280535.1	ribonucleoside-diphosphate reductase subunit alpha	-
PSYC_RS06560	1523098..1523886	+	789	WP_011280536.1	hypothetical protein	-
PSYC_RS06565	1524362..1524613	+	252	WP_011280537.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
PSYC_RS06570	1524603..1524890	+	288	WP_011280538.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
PSYC_RS06575	1524976..1525323	+	348	WP_041758023.1	hypothetical protein	-
PSYC_RS06580	1525414..1526547	+	1134	WP_011280540.1	ribonucleotide-diphosphate reductase subunit beta	-
PSYC_RS06585	1526770..1527030	+	261	WP_011280541.1	2Fe-2S iron-sulfur cluster binding domain-containing protein	-
PSYC_RS06590	1527217..1528545	-	1329	WP_011280542.1	trypsin-like peptidase domain-containing protein	-
PSYC_RS06595	1528949..1529785	+	837	WP_011280543.1	Nif3-like dinuclear metal center hexameric protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (8-72)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11054.85 Da
• Isoelectric Point: 10.4986

>T21216 WP_011280538.1 NC_007204:1524603-1524890 [Psychrobacter arcticus 273-4]
MTYNLEFHPLALKEWKKIAPSIQQQFKKKLQQRLSNPHVPASQLSGHNDTYKIKLRTIGYRLVYTVKDDVVVVYVLAVGK
RENNKVYDSLATRQP

Nucleotide

• Length: 288 bp

>T21216 NC_007204:1524603-1524890 [Psychrobacter arcticus 273-4]
ATGACTTATAATCTTGAGTTTCATCCTTTAGCATTAAAAGAGTGGAAAAAGATAGCGCCAAGTATTCAGCAGCAGTTTAA
GAAAAAATTACAGCAGCGATTGTCAAACCCTCATGTGCCTGCTTCACAGTTATCAGGTCATAATGATACTTATAAAATTA
AATTGCGCACGATAGGATATCGTCTGGTGTATACCGTCAAAGATGATGTCGTCGTTGTATACGTGCTAGCAGTAGGCAAA
AGAGAAAATAACAAAGTGTATGACAGTCTTGCGACACGCCAGCCATGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9093.38 Da
• Isoelectric Point: 4.2493

>AT21216 WP_011280537.1 NC_007204:1524362-1524613 [Psychrobacter arcticus 273-4]
MQPIFATQTASISELKNNPSALIKQSDGESIAILNHNKPVAYLVSTDVFERMMEAMDDMALSQTVSARLNDGQIPIKVTL
DDL

Nucleotide

• Length: 252 bp

>AT21216 NC_007204:1524362-1524613 [Psychrobacter arcticus 273-4]
ATGCAACCAATATTTGCAACACAAACAGCGAGTATCTCAGAGCTGAAAAACAACCCTTCGGCACTGATTAAACAGTCAGA
TGGTGAATCCATTGCTATTTTAAACCACAATAAACCCGTGGCTTACTTAGTCTCAACAGACGTCTTCGAGCGCATGATGG
AAGCGATGGATGATATGGCTTTAAGCCAAACGGTTAGCGCACGGTTGAATGATGGGCAGATACCTATAAAGGTAACGTTG
GATGACTTATAA

Structures

Toxin

• AlphaFold DB: Q4FS92

Antitoxin

• AlphaFold DB: Q4FS93