Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 833464..833941 Replicon chromosome
Accession NZ_CP080564
Organism Staphylococcus aureus strain HL16278

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag JMO07_RS03940 Protein ID WP_000052076.1
Coordinates 833464..833652 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag JMO07_RS03945 Protein ID WP_001059690.1
Coordinates 833681..833941 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMO07_RS03910 (829454) 829454..829975 + 522 WP_000824484.1 hypothetical protein -
JMO07_RS03915 (830316) 830316..831002 + 687 WP_001792695.1 thermonuclease family protein -
JMO07_RS03920 (831359) 831359..831559 + 201 WP_001059082.1 cold-shock protein -
JMO07_RS03925 (832055) 832055..832273 - 219 WP_000005886.1 hypothetical protein -
JMO07_RS03930 (832335) 832335..832619 - 285 WP_001004395.1 hypothetical protein -
JMO07_RS03935 (832707) 832707..833276 - 570 WP_001106654.1 lipoprotein N-acylation protein LnsA -
JMO07_RS03940 (833464) 833464..833652 - 189 WP_000052076.1 hypothetical protein Toxin
JMO07_RS03945 (833681) 833681..833941 - 261 WP_001059690.1 hypothetical protein Antitoxin
JMO07_RS03950 (834282) 834282..834485 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
JMO07_RS03955 (834482) 834482..834718 - 237 WP_000368687.1 hypothetical protein -
JMO07_RS03960 (834943) 834943..835524 + 582 WP_001140693.1 histidine phosphatase family protein -
JMO07_RS03965 (835597) 835597..836214 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
JMO07_RS03970 (836369) 836369..836863 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
JMO07_RS03975 (837262) 837262..837684 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
JMO07_RS03980 (837832) 837832..838548 + 717 WP_000150012.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(6-104)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T212154 WP_000052076.1 NZ_CP080564:c833652-833464 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T212154 NZ_CP106995:3743321-3743662 [Escherichia coli]
ATGAAAACTTTACCTGCAATAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTAGAAAAATACGAGCTGGTTCGTATCGACAGGAAGGGATTT
AGCTGGCAGGAACAATCTCCTTATCTCCGGGCTGCAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT212154 WP_001059690.1 NZ_CP080564:c833941-833681 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT212154 NZ_CP106995:3742983-3743300 [Escherichia coli]
ATGAGCAACCCTACCAGGGGCCTGCAGCGGGAGATTACACTGCGCCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGCAAGTTCAGTGACATCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCTCCAGATGGAATCGATGCTGACCACCGGTGAACTCAGCCCCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTAACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References