212153

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 2661509..2662032 Replicon chromosome
Accession NZ_CP080562
Organism Staphylococcus aureus strain HL21008

Toxin (Protein)


Gene name relE Uniprot ID A0A3A5LQI3
Locus tag JMO08_RS13470 Protein ID WP_000074049.1
Coordinates 2661509..2661775 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag JMO08_RS13475 Protein ID WP_000587616.1
Coordinates 2661775..2662032 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMO08_RS13450 (JMO08_002690) 2656816..2658003 - 1188 WP_000026189.1 MFS transporter -
JMO08_RS13455 (JMO08_002691) 2658399..2659175 - 777 WP_000072149.1 iron export ABC transporter permease subunit FetB -
JMO08_RS13460 (JMO08_002692) 2659168..2659830 - 663 WP_000923526.1 ATP-binding cassette domain-containing protein -
JMO08_RS13465 (JMO08_002693) 2660078..2661154 - 1077 WP_001076673.1 M42 family metallopeptidase -
JMO08_RS13470 (JMO08_002694) 2661509..2661775 - 267 WP_000074049.1 Txe/YoeB family addiction module toxin Toxin
JMO08_RS13475 (JMO08_002695) 2661775..2662032 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JMO08_RS13480 (JMO08_002696) 2662391..2662846 + 456 WP_000732076.1 DUF1307 domain-containing protein -
JMO08_RS13485 (JMO08_002697) 2663014..2664591 - 1578 WP_000143494.1 FMN-binding glutamate synthase family protein -
JMO08_RS13490 (JMO08_002698) 2664786..2665535 + 750 WP_000072461.1 CPBP family lipoprotein N-acylation protein LnsB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10676.24 Da        Isoelectric Point: 10.1597

>T212153 WP_000074049.1 NZ_CP080562:c2661775-2661509 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLRKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T212153 NZ_CP106995:3561455-3561673 [Escherichia coli]
ATGTCCGAAAAATTTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT212153 WP_000587616.1 NZ_CP080562:c2662032-2661775 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT212153 NZ_CP106995:3561055-3561429 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A5LQI3

Antitoxin

Source ID Structure
AlphaFold DB W8TQT5

References