Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2243911..2244425 Replicon chromosome
Accession NZ_CP080562
Organism Staphylococcus aureus strain HL21008

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag JMO08_RS11230 Protein ID WP_000581792.1
Coordinates 2243911..2244120 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag JMO08_RS11235 Protein ID WP_000138932.1
Coordinates 2244132..2244425 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMO08_RS11210 (JMO08_002242) 2239419..2240777 - 1359 WP_000611464.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
JMO08_RS11215 (JMO08_002243) 2240792..2241862 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
JMO08_RS11220 (JMO08_002244) 2242180..2243382 + 1203 WP_044425300.1 FtsW/RodA/SpoVE family cell cycle protein -
JMO08_RS11225 (JMO08_002245) 2243646..2243783 - 138 WP_000828354.1 Lmo0850 family protein -
JMO08_RS11230 (JMO08_002246) 2243911..2244120 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
JMO08_RS11235 (JMO08_002247) 2244132..2244425 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
JMO08_RS11240 (JMO08_002248) 2244591..2246075 + 1485 WP_000571549.1 cardiolipin synthase -
JMO08_RS11245 (JMO08_002249) 2246103..2246750 + 648 WP_001187630.1 HD domain-containing protein -
JMO08_RS11250 (JMO08_002250) 2247363..2248235 - 873 WP_000725802.1 membrane protein insertase YidC -
JMO08_RS11255 (JMO08_002251) 2248321..2248962 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T212144 WP_000581792.1 NZ_CP080562:c2244120-2243911 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T212144 NZ_CP106995:1800235-1800486 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT212144 WP_000138932.1 NZ_CP080562:c2244425-2244132 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT212144 NZ_CP106995:1800483-1800737 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References