Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TscAT/- |
| Location | 2170543..2171081 | Replicon | chromosome |
| Accession | NZ_CP080562 | ||
| Organism | Staphylococcus aureus strain HL21008 | ||
Toxin (Protein)
| Gene name | TscT | Uniprot ID | A0A0H3K0C1 |
| Locus tag | JMO08_RS10865 | Protein ID | WP_001078344.1 |
| Coordinates | 2170543..2170869 (-) | Length | 109 a.a. |
Antitoxin (Protein)
| Gene name | TscA | Uniprot ID | A0A0H3JSN0 |
| Locus tag | JMO08_RS10870 | Protein ID | WP_001058495.1 |
| Coordinates | 2170872..2171081 (-) | Length | 70 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JMO08_RS10840 (JMO08_002168) | 2165767..2166108 | - | 342 | WP_001190615.1 | hypothetical protein | - |
| JMO08_RS10845 (JMO08_002169) | 2166558..2167199 | - | 642 | WP_001047698.1 | hypothetical protein | - |
| JMO08_RS10850 (JMO08_002170) | 2167196..2167576 | - | 381 | WP_000356942.1 | hypothetical protein | - |
| JMO08_RS10855 (JMO08_002171) | 2167886..2169595 | - | 1710 | WP_000447473.1 | DUF927 domain-containing protein | - |
| JMO08_RS10860 (JMO08_002172) | 2169609..2170478 | - | 870 | WP_001002689.1 | primase alpha helix C-terminal domain-containing protein | - |
| JMO08_RS10865 (JMO08_002173) | 2170543..2170869 | - | 327 | WP_001078344.1 | DUF1474 family protein | Toxin |
| JMO08_RS10870 (JMO08_002174) | 2170872..2171081 | - | 210 | WP_001058495.1 | hypothetical protein | Antitoxin |
| JMO08_RS10875 (JMO08_002175) | 2171074..2171220 | - | 147 | WP_000784885.1 | hypothetical protein | - |
| JMO08_RS10880 (JMO08_002176) | 2171217..2171534 | - | 318 | WP_000481967.1 | helix-turn-helix domain-containing protein | - |
| JMO08_RS10885 (JMO08_002177) | 2171539..2171757 | - | 219 | WP_000153640.1 | helix-turn-helix transcriptional regulator | - |
| JMO08_RS10890 (JMO08_002178) | 2171930..2172604 | + | 675 | WP_000620857.1 | helix-turn-helix transcriptional regulator | - |
| JMO08_RS10895 (JMO08_002179) | 2172618..2173790 | + | 1173 | WP_000179343.1 | tyrosine-type recombinase/integrase | - |
| JMO08_RS10900 (JMO08_002180) | 2173859..2175475 | - | 1617 | WP_000240642.1 | chaperonin GroEL | - |
| JMO08_RS10905 (JMO08_002181) | 2175551..2175835 | - | 285 | WP_000917289.1 | co-chaperone GroES | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | sell / sec / tsst-1 / groEL | 2152157..2175835 | 23678 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 109 a.a. Molecular weight: 12968.26 Da Isoelectric Point: 4.3050
>T212142 WP_001078344.1 NZ_CP080562:c2170869-2170543 [Staphylococcus aureus]
MNREIKDLFSDLKLLKDSFEDLKDSNGWHFDELYPYEPNHVLNKDELIGEGFSYHERRIHNNQMFDLFHLYIEQFDNIIE
KFYEIEKASSENFGEESDDAKNSIKVAE
MNREIKDLFSDLKLLKDSFEDLKDSNGWHFDELYPYEPNHVLNKDELIGEGFSYHERRIHNNQMFDLFHLYIEQFDNIIE
KFYEIEKASSENFGEESDDAKNSIKVAE
Download Length: 327 bp
>T212142 NZ_CP106995:c1111740-1111411 [Escherichia coli]
ATGAACACTCTACCTGCTACAATTTCGCAGGCGGCGAAGCCCTGCCTGTCGCCAGTGGCTGTCTGGCAAATGCTACTGAC
ACGCCTGCTGGAACAACACTATGGCCTGACACTGAACGACACGCCGTTCAGTGATGAAACTGTTATTAAGGAACATATCG
ATGCTGGTATCACTCTGGCCGATGCAGTCAATTTTCTGGTGGAAAAGTACGAACTGGTACGTATCGATCACAGAGGATTT
TCGTGGCAACAACAGTCTCCATATATTTCCGTAGTAGATATTCTGCGAGCAAGGCGCTCTACCGGCTTGCTAAAAACTAA
TGTGAAATAA
ATGAACACTCTACCTGCTACAATTTCGCAGGCGGCGAAGCCCTGCCTGTCGCCAGTGGCTGTCTGGCAAATGCTACTGAC
ACGCCTGCTGGAACAACACTATGGCCTGACACTGAACGACACGCCGTTCAGTGATGAAACTGTTATTAAGGAACATATCG
ATGCTGGTATCACTCTGGCCGATGCAGTCAATTTTCTGGTGGAAAAGTACGAACTGGTACGTATCGATCACAGAGGATTT
TCGTGGCAACAACAGTCTCCATATATTTCCGTAGTAGATATTCTGCGAGCAAGGCGCTCTACCGGCTTGCTAAAAACTAA
TGTGAAATAA
Antitoxin
Download Length: 70 a.a. Molecular weight: 8206.22 Da Isoelectric Point: 4.3718
>AT212142 WP_001058495.1 NZ_CP080562:c2171081-2170872 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVVNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE
MNNEQKEVIEHVVYQLELSVVNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE
Download Length: 210 bp
>AT212142 NZ_CP106995:c1112078-1111761 [Escherichia coli]
ATGAGCAACACCACATGGGGCCTGCAGCGAGATATCACGCCGCGCCTGGGAGCACGTCTGGTGCAGGAGGGCAACCAGCT
GCACTATCTGGCTGACCGGGCCAGTATCACCGGTAAGTTTAGTGACGCCGAATGTCCTAAGCTGGATGTGGTATTTCCAC
ATTTTATCAGCCAGATAGAGTCGATGCTGACCACTGGTGAACTGAATCCCCGCCATGCCCAATGCGTCACCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACTCTTGGTAGTTGCGGCTACGTATACATCGCTGTTTACCCCACTCAACGCTAA
ATGAGCAACACCACATGGGGCCTGCAGCGAGATATCACGCCGCGCCTGGGAGCACGTCTGGTGCAGGAGGGCAACCAGCT
GCACTATCTGGCTGACCGGGCCAGTATCACCGGTAAGTTTAGTGACGCCGAATGTCCTAAGCTGGATGTGGTATTTCCAC
ATTTTATCAGCCAGATAGAGTCGATGCTGACCACTGGTGAACTGAATCCCCGCCATGCCCAATGCGTCACCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACTCTTGGTAGTTGCGGCTACGTATACATCGCTGTTTACCCCACTCAACGCTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3K0C1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3JSN0 |