Detailed information of TA system TA021213

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/AbrB(antitoxin)
• Location: 1779782..1780285
• Replicon: chromosome
• Accession: NC_007181
• Organism: Sulfolobus acidocaldarius DSM 639

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: SACI_RS12000
• Protein ID: WP_162465564.1
• Coordinates: 1780130..1780285 (+)
• Length: 52 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: M1I7E0
• Locus tag: SACI_RS09520
• Protein ID: WP_011278775.1
• Coordinates: 1779782..1780024 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SACI_RS09500 (Saci_1966)	1775294..1776781	+	1488	WP_230949672.1	AMP-binding protein	-
SACI_RS09505 (Saci_1967)	1776768..1777886	+	1119	WP_011278772.1	arabinonate dehydratase	-
SACI_RS09510 (Saci_1968)	1777888..1779048	+	1161	WP_011278773.1	thiolase family protein	-
SACI_RS09515 (Saci_1969)	1779041..1779385	+	345	WP_011278774.1	zinc ribbon domain-containing protein	-
SACI_RS09520 (Saci_1970)	1779782..1780024	+	243	WP_011278775.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
SACI_RS12000	1780130..1780285	+	156	WP_162465564.1	hypothetical protein	Toxin
SACI_RS09525 (Saci_1972)	1780744..1782069	+	1326	WP_015385888.1	APC family permease	-
SACI_RS09530 (Saci_1973)	1782228..1784474	+	2247	WP_011278777.1	MMPL family transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• SpoVT-AbrB domain (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5963.78 Da
• Isoelectric Point: 4.1435

>T21213 WP_162465564.1 NC_007181:1780130-1780285 [Sulfolobus acidocaldarius DSM 639]
VEIAYFLVKNGIEVRSVIESTLSDPKVEVIENILEDLYFAIRSEPRKYDDF

Nucleotide

• Length: 156 bp

>T21213 NC_007181:1780130-1780285 [Sulfolobus acidocaldarius DSM 639]
GTGGAAATTGCTTACTTCTTGGTGAAGAATGGGATTGAAGTCAGGAGCGTCATAGAGAGTACACTCAGTGACCCTAAAGT
GGAAGTTATCGAGAACATCCTTGAGGACTTGTATTTTGCAATAAGGAGTGAGCCAAGAAAATATGATGACTTTTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9009.48 Da
• Isoelectric Point: 8.9835

>AT21213 WP_011278775.1 NC_007181:1779782-1780024 [Sulfolobus acidocaldarius DSM 639]
MFEESRVTRNYRITIPATIRQKLGIRVGDKLIVYTEGDKIILVKKKGDLVSLNLKLGRKFTDEEVNKVIEEAGEEVGGSC

Nucleotide

• Length: 243 bp

>AT21213 NC_007181:1779782-1780024 [Sulfolobus acidocaldarius DSM 639]
ATGTTTGAAGAGAGCAGAGTCACCAGGAATTACCGAATAACAATACCAGCTACTATCAGGCAAAAACTGGGAATCAGGGT
CGGTGATAAACTCATAGTGTATACCGAGGGTGATAAAATAATACTGGTCAAAAAGAAGGGTGACTTAGTGTCCTTAAACC
TAAAGTTAGGTAGGAAGTTTACTGATGAAGAGGTCAATAAAGTAATAGAGGAAGCAGGAGAGGAAGTTGGAGGGAGTTGT
TGA

Structures

Antitoxin

• AlphaFold DB: M1I7E0