Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2271689..2272203 Replicon chromosome
Accession NZ_CP080560
Organism Staphylococcus aureus strain HL17064

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag JMO09_RS11410 Protein ID WP_000581792.1
Coordinates 2271689..2271898 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag JMO09_RS11415 Protein ID WP_000138932.1
Coordinates 2271910..2272203 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMO09_RS11390 (JMO09_002278) 2267197..2268555 - 1359 WP_000611464.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
JMO09_RS11395 (JMO09_002279) 2268570..2269640 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
JMO09_RS11400 (JMO09_002280) 2269958..2271160 + 1203 WP_044425300.1 FtsW/RodA/SpoVE family cell cycle protein -
JMO09_RS11405 (JMO09_002281) 2271424..2271561 - 138 WP_000828354.1 Lmo0850 family protein -
JMO09_RS11410 (JMO09_002282) 2271689..2271898 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
JMO09_RS11415 (JMO09_002283) 2271910..2272203 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
JMO09_RS11420 (JMO09_002284) 2272369..2273853 + 1485 WP_220374343.1 cardiolipin synthase -
JMO09_RS11425 (JMO09_002285) 2273881..2274528 + 648 WP_001187630.1 HD domain-containing protein -
JMO09_RS11430 (JMO09_002286) 2275141..2276013 - 873 WP_000725802.1 membrane protein insertase YidC -
JMO09_RS11435 (JMO09_002287) 2276099..2276740 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T212128 WP_000581792.1 NZ_CP080560:c2271898-2271689 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T212128 NZ_CP106994:2671044-2671151 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT212128 WP_000138932.1 NZ_CP080560:c2272203-2271910 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT212128 NZ_CP106994:c2670997-2670931 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References