212127

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2250430..2250959 Replicon chromosome
Accession NZ_CP080560
Organism Staphylococcus aureus strain HL17064

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag JMO09_RS11315 Protein ID WP_000621175.1
Coordinates 2250430..2250792 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag JMO09_RS11320 Protein ID WP_000948331.1
Coordinates 2250789..2250959 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMO09_RS11295 (JMO09_002259) 2247409..2248179 - 771 WP_001041106.1 RNA polymerase sigma factor SigB -
JMO09_RS11300 (JMO09_002260) 2248154..2248633 - 480 WP_044421339.1 anti-sigma B factor RsbW -
JMO09_RS11305 (JMO09_002261) 2248635..2248961 - 327 WP_001052491.1 anti-sigma factor antagonist -
JMO09_RS11310 (JMO09_002262) 2249080..2250081 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
JMO09_RS11315 (JMO09_002263) 2250430..2250792 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JMO09_RS11320 (JMO09_002264) 2250789..2250959 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
JMO09_RS11325 (JMO09_002265) 2251044..2252192 - 1149 WP_001281154.1 alanine racemase -
JMO09_RS11330 (JMO09_002266) 2252258..2252617 - 360 WP_000581197.1 holo-ACP synthase -
JMO09_RS11335 (JMO09_002267) 2252621..2253112 - 492 WP_001205912.1 PH domain-containing protein -
JMO09_RS11340 (JMO09_002268) 2253099..2254682 - 1584 WP_001294626.1 PH domain-containing protein -
JMO09_RS11345 (JMO09_002269) 2254675..2255154 - 480 WP_001287087.1 hypothetical protein -
JMO09_RS11350 (JMO09_002270) 2255362..2255922 - 561 WP_001092411.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T212127 WP_000621175.1 NZ_CP080560:c2250792-2250430 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

>T212127 NZ_CP106994:2670509-2670616 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT212127 WP_000948331.1 NZ_CP080560:c2250959-2250789 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT212127 NZ_CP106994:c2670462-2670396 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References