Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 2097215..2097991 Replicon chromosome
Accession NZ_CP080560
Organism Staphylococcus aureus strain HL17064

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag JMO09_RS10430 Protein ID WP_000031108.1
Coordinates 2097215..2097367 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag JMO09_RS10435 Protein ID WP_001251224.1
Coordinates 2097392..2097991 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMO09_RS10415 (JMO09_002083) 2093417..2094238 + 822 WP_000669376.1 RluA family pseudouridine synthase -
JMO09_RS10420 (JMO09_002084) 2094691..2096076 - 1386 WP_000116228.1 class II fumarate hydratase -
JMO09_RS10425 (JMO09_002085) 2096272..2096667 - 396 WP_000901023.1 hypothetical protein -
JMO09_RS10430 (JMO09_002086) 2097215..2097367 - 153 WP_000031108.1 SAS053 family protein Toxin
JMO09_RS10435 (JMO09_002087) 2097392..2097991 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
JMO09_RS10440 (JMO09_002088) 2098150..2098620 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
JMO09_RS10445 (JMO09_002089) 2098625..2099752 - 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
JMO09_RS10450 (JMO09_002090) 2099903..2100625 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
JMO09_RS10455 (JMO09_002091) 2100618..2102075 - 1458 WP_000649908.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T212126 WP_000031108.1 NZ_CP080560:c2097367-2097215 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T212126 NZ_CP106994:c2382413-2382237 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT212126 WP_001251224.1 NZ_CP080560:c2097991-2097392 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT212126 NZ_CP106994:c2382191-2381775 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References