Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 878472..878949 Replicon chromosome
Accession NZ_CP080560
Organism Staphylococcus aureus strain HL17064

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag JMO09_RS04135 Protein ID WP_000052076.1
Coordinates 878472..878660 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag JMO09_RS04140 Protein ID WP_001059690.1
Coordinates 878689..878949 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMO09_RS04105 (JMO09_000821) 874466..874987 + 522 WP_000824482.1 hypothetical protein -
JMO09_RS04110 (JMO09_000822) 875328..876014 + 687 WP_000141557.1 thermonuclease family protein -
JMO09_RS04115 (JMO09_000823) 876371..876571 + 201 WP_001059082.1 cold-shock protein -
JMO09_RS04120 (JMO09_000824) 877063..877281 - 219 WP_000005886.1 hypothetical protein -
JMO09_RS04125 (JMO09_000825) 877343..877627 - 285 WP_044423470.1 hypothetical protein -
JMO09_RS04130 (JMO09_000826) 877715..878284 - 570 WP_001106654.1 lipoprotein N-acylation protein LnsA -
JMO09_RS04135 (JMO09_000827) 878472..878660 - 189 WP_000052076.1 hypothetical protein Toxin
JMO09_RS04140 (JMO09_000828) 878689..878949 - 261 WP_001059690.1 hypothetical protein Antitoxin
JMO09_RS04145 (JMO09_000829) 879290..879493 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
JMO09_RS04150 (JMO09_000830) 879490..879726 - 237 WP_000349581.1 hypothetical protein -
JMO09_RS04155 (JMO09_000831) 879951..880532 + 582 WP_001140693.1 histidine phosphatase family protein -
JMO09_RS04160 (JMO09_000832) 880605..881222 - 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
JMO09_RS04165 (JMO09_000833) 881377..881871 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
JMO09_RS04170 (JMO09_000834) 882270..882692 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
JMO09_RS04175 (JMO09_000835) 882840..883556 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)

Antitoxin

Toxin YoeB

(5-84)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T212120 WP_000052076.1 NZ_CP080560:c878660-878472 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T212120 NZ_CP106994:1800235-1800486 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT212120 WP_001059690.1 NZ_CP080560:c878949-878689 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT212120 NZ_CP106994:1800483-1800737 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References