Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2256226..2256740 Replicon chromosome
Accession NZ_CP080556
Organism Staphylococcus aureus strain HL17078

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag JMO10_RS11390 Protein ID WP_000581792.1
Coordinates 2256226..2256435 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag JMO10_RS11395 Protein ID WP_000138932.1
Coordinates 2256447..2256740 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMO10_RS11370 (2251734) 2251734..2253092 - 1359 WP_000611462.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
JMO10_RS11375 (2253107) 2253107..2254177 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
JMO10_RS11380 (2254495) 2254495..2255697 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
JMO10_RS11385 (2255961) 2255961..2256098 - 138 WP_000828354.1 Lmo0850 family protein -
JMO10_RS11390 (2256226) 2256226..2256435 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
JMO10_RS11395 (2256447) 2256447..2256740 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
JMO10_RS11400 (2256906) 2256906..2258390 + 1485 WP_000571549.1 cardiolipin synthase -
JMO10_RS11405 (2258418) 2258418..2259065 + 648 WP_001187629.1 HD domain-containing protein -
JMO10_RS11410 (2259878) 2259878..2260750 - 873 WP_000725802.1 membrane protein insertase YidC -
JMO10_RS11415 (2260836) 2260836..2261477 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T212112 WP_000581792.1 NZ_CP080556:c2256435-2256226 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T212112 NZ_CP106994:183125-183232 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT212112 WP_000138932.1 NZ_CP080556:c2256740-2256447 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT212112 NZ_CP106994:c183077-183011 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References