Detailed information of TA system TA212103

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 887831..888308
• Replicon: chromosome
• Accession: NZ_CP080556
• Organism: Staphylococcus aureus strain HL17078

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: Q2G005
• Locus tag: JMO10_RS04255
• Protein ID: WP_000052078.1
• Coordinates: 887831..888019 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: JMO10_RS04260
• Protein ID: WP_001059690.1
• Coordinates: 888048..888308 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMO10_RS04225 (883872)	883872..884342	+	471	WP_000824472.1	hypothetical protein	-
JMO10_RS04230 (884683)	884683..885369	+	687	WP_001548082.1	thermonuclease family protein	-
JMO10_RS04235 (885726)	885726..885926	+	201	WP_001059082.1	cold-shock protein	-
JMO10_RS04240 (886422)	886422..886640	-	219	WP_000005886.1	hypothetical protein	-
JMO10_RS04245 (886702)	886702..886986	-	285	WP_001004395.1	hypothetical protein	-
JMO10_RS04250 (887074)	887074..887643	-	570	WP_001106654.1	lipoprotein N-acylation protein LnsA	-
JMO10_RS04255 (887831)	887831..888019	-	189	WP_000052078.1	hypothetical protein	Toxin
JMO10_RS04260 (888048)	888048..888308	-	261	WP_001059690.1	hypothetical protein	Antitoxin
JMO10_RS04265 (888649)	888649..888852	+	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
JMO10_RS04270 (888849)	888849..889085	-	237	WP_000368687.1	hypothetical protein	-
JMO10_RS04275 (889310)	889310..889891	+	582	WP_001140686.1	histidine phosphatase family protein	-
JMO10_RS04280 (889964)	889964..890581	-	618	WP_000255561.1	LysE/ArgO family amino acid transporter	-
JMO10_RS04285 (890736)	890736..891230	-	495	WP_000569884.1	GNAT family N-acetyltransferase	-
JMO10_RS04290 (891629)	891629..892051	-	423	WP_000974460.1	organic hydroperoxide resistance protein	-
JMO10_RS04295 (892199)	892199..892915	+	717	WP_000150017.1	type I 3-dehydroquinate dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	selk / selq	884683..913597	28914

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-129)

Antitoxin

• SpoVT-AbrB domain (7-50)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7172.84 Da
• Isoelectric Point: 9.9971

>T212103 WP_000052078.1 NZ_CP080556:c888019-887831 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T212103 NZ_CP106965:8612-9028 [Klebsiella variicola]
GTGAACAAAATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGGGGTCACCGCATTGTGGTTTCGGCCATTACCTACGCCGAGATGCGCTTCGGCGCCACCGGGC
CGAAGGCCGCGCCGCGTCACGTCCAGCTGGTTGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCC
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGCATGGCCGGCACGCCGATTGGCCCGAACGACACGGCGATTGC
CGGACACGCCATCGCCGCCGGCGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT212103 WP_001059690.1 NZ_CP080556:c888308-888048 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT212103 NZ_CP106965:8385-8615 [Klebsiella variicola]
ATGCGCACAGTCTCTATTTTTAAAAACGGCAACAACCGCGCCATCCGTCTGCCCCGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATCCTGCGTCCCGTCCGGCCGACCTGGGGTTCGTTCGCGCAGCTCG
AAAAAGCTGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGGGTTAACCTGTGA

Structures

Toxin

• AlphaFold DB: A0A0D6HZ40

Antitoxin

• AlphaFold DB: A0A0E0VN56