Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2252656..2253170 Replicon chromosome
Accession NZ_CP080553
Organism Staphylococcus aureus strain HL18380

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag JMO11_RS11375 Protein ID WP_000581792.1
Coordinates 2252656..2252865 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag JMO11_RS11380 Protein ID WP_000138932.1
Coordinates 2252877..2253170 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMO11_RS11355 (2248164) 2248164..2249522 - 1359 WP_000611462.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
JMO11_RS11360 (2249537) 2249537..2250607 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
JMO11_RS11365 (2250925) 2250925..2252127 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
JMO11_RS11370 (2252391) 2252391..2252528 - 138 WP_000828354.1 Lmo0850 family protein -
JMO11_RS11375 (2252656) 2252656..2252865 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
JMO11_RS11380 (2252877) 2252877..2253170 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
JMO11_RS11385 (2253336) 2253336..2254820 + 1485 WP_000571549.1 cardiolipin synthase -
JMO11_RS11390 (2254848) 2254848..2255495 + 648 WP_001187629.1 HD domain-containing protein -
JMO11_RS11395 (2256308) 2256308..2257180 - 873 WP_000725802.1 membrane protein insertase YidC -
JMO11_RS11400 (2257266) 2257266..2257907 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T212095 WP_000581792.1 NZ_CP080553:c2252865-2252656 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T212095 NZ_CP106964:1944845-1944947 [Klebsiella variicola]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT212095 WP_000138932.1 NZ_CP080553:c2253170-2252877 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT212095 NZ_CP106964:c1944953-1944809 [Klebsiella variicola]
ACCGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGT
TGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References