Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 885429..885906 Replicon chromosome
Accession NZ_CP080553
Organism Staphylococcus aureus strain HL18380

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag JMO11_RS04240 Protein ID WP_000052078.1
Coordinates 885429..885617 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag JMO11_RS04245 Protein ID WP_001059690.1
Coordinates 885646..885906 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMO11_RS04210 (881470) 881470..881940 + 471 WP_000824472.1 hypothetical protein -
JMO11_RS04215 (882281) 882281..882967 + 687 WP_001548082.1 thermonuclease family protein -
JMO11_RS04220 (883324) 883324..883524 + 201 WP_001059082.1 cold-shock protein -
JMO11_RS04225 (884020) 884020..884238 - 219 WP_000005886.1 hypothetical protein -
JMO11_RS04230 (884300) 884300..884584 - 285 WP_001004395.1 hypothetical protein -
JMO11_RS04235 (884672) 884672..885241 - 570 WP_001106654.1 lipoprotein N-acylation protein LnsA -
JMO11_RS04240 (885429) 885429..885617 - 189 WP_000052078.1 hypothetical protein Toxin
JMO11_RS04245 (885646) 885646..885906 - 261 WP_001059690.1 hypothetical protein Antitoxin
JMO11_RS04250 (886247) 886247..886450 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
JMO11_RS04255 (886447) 886447..886683 - 237 WP_000368687.1 hypothetical protein -
JMO11_RS04260 (886908) 886908..887489 + 582 WP_001140686.1 histidine phosphatase family protein -
JMO11_RS04265 (887562) 887562..888179 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
JMO11_RS04270 (888334) 888334..888828 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
JMO11_RS04275 (889227) 889227..889649 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
JMO11_RS04280 (889797) 889797..890513 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin YafO

(27-130)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T212085 WP_000052078.1 NZ_CP080553:c885617-885429 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T212085 NZ_CP106929:4101915-4102313 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT212085 WP_001059690.1 NZ_CP080553:c885906-885646 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT212085 NZ_CP106929:4101619-4101912 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References