212084

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 2617806..2618329 Replicon chromosome
Accession NZ_CP080552
Organism Staphylococcus aureus strain HL18807

Toxin (Protein)


Gene name relE Uniprot ID A0A3A5LQI3
Locus tag JMO12_RS13185 Protein ID WP_000074049.1
Coordinates 2617806..2618072 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag JMO12_RS13190 Protein ID WP_000587616.1
Coordinates 2618072..2618329 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMO12_RS13165 (JMO12_002634) 2613113..2614300 - 1188 WP_000026189.1 MFS transporter -
JMO12_RS13170 (JMO12_002635) 2614696..2615472 - 777 WP_000072149.1 iron export ABC transporter permease subunit FetB -
JMO12_RS13175 (JMO12_002636) 2615465..2616127 - 663 WP_220360767.1 ATP-binding cassette domain-containing protein -
JMO12_RS13180 (JMO12_002637) 2616375..2617451 - 1077 WP_001076673.1 M42 family metallopeptidase -
JMO12_RS13185 (JMO12_002638) 2617806..2618072 - 267 WP_000074049.1 Txe/YoeB family addiction module toxin Toxin
JMO12_RS13190 (JMO12_002639) 2618072..2618329 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JMO12_RS13195 (JMO12_002640) 2618688..2619143 + 456 WP_000732076.1 DUF1307 domain-containing protein -
JMO12_RS13200 (JMO12_002641) 2619311..2620888 - 1578 WP_000143494.1 FMN-binding glutamate synthase family protein -
JMO12_RS13205 (JMO12_002642) 2621083..2621832 + 750 WP_000072461.1 CPBP family lipoprotein N-acylation protein LnsB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10676.24 Da        Isoelectric Point: 10.1597

>T212084 WP_000074049.1 NZ_CP080552:c2618072-2617806 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLRKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T212084 NZ_CP106929:c4095853-4095575 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT212084 WP_000587616.1 NZ_CP080552:c2618329-2618072 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT212084 NZ_CP106929:c4096116-4095856 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A5LQI3

Antitoxin

Source ID Structure
AlphaFold DB W8TQT5

References