Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2244452..2244966 Replicon chromosome
Accession NZ_CP080552
Organism Staphylococcus aureus strain HL18807

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag JMO12_RS11245 Protein ID WP_000581792.1
Coordinates 2244452..2244661 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag JMO12_RS11250 Protein ID WP_000138932.1
Coordinates 2244673..2244966 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMO12_RS11225 (JMO12_002247) 2239960..2241318 - 1359 WP_000611464.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
JMO12_RS11230 (JMO12_002248) 2241333..2242403 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
JMO12_RS11235 (JMO12_002249) 2242721..2243923 + 1203 WP_044425300.1 FtsW/RodA/SpoVE family cell cycle protein -
JMO12_RS11240 (JMO12_002250) 2244187..2244324 - 138 WP_000828354.1 Lmo0850 family protein -
JMO12_RS11245 (JMO12_002251) 2244452..2244661 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
JMO12_RS11250 (JMO12_002252) 2244673..2244966 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
JMO12_RS11255 (JMO12_002253) 2245132..2246616 + 1485 WP_000571549.1 cardiolipin synthase -
JMO12_RS11260 (JMO12_002254) 2246644..2247291 + 648 WP_001187630.1 HD domain-containing protein -
JMO12_RS11265 (JMO12_002255) 2247904..2248776 - 873 WP_000725802.1 membrane protein insertase YidC -
JMO12_RS11270 (JMO12_002256) 2248862..2249503 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T212080 WP_000581792.1 NZ_CP080552:c2244661-2244452 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T212080 NZ_CP080552:c2244661-2244452 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT212080 WP_000138932.1 NZ_CP080552:c2244966-2244673 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT212080 NZ_CP080552:c2244966-2244673 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References