Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TscAT/- |
| Location | 2171045..2171583 | Replicon | chromosome |
| Accession | NZ_CP080552 | ||
| Organism | Staphylococcus aureus strain HL18807 | ||
Toxin (Protein)
| Gene name | TscT | Uniprot ID | A0A0H3K0C1 |
| Locus tag | JMO12_RS10880 | Protein ID | WP_001078344.1 |
| Coordinates | 2171045..2171371 (-) | Length | 109 a.a. |
Antitoxin (Protein)
| Gene name | TscA | Uniprot ID | A0A0H3JSN0 |
| Locus tag | JMO12_RS10885 | Protein ID | WP_001058495.1 |
| Coordinates | 2171374..2171583 (-) | Length | 70 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JMO12_RS10855 (JMO12_002173) | 2166269..2166610 | - | 342 | WP_001190615.1 | hypothetical protein | - |
| JMO12_RS10860 (JMO12_002174) | 2167060..2167701 | - | 642 | WP_001047698.1 | hypothetical protein | - |
| JMO12_RS10865 (JMO12_002175) | 2167698..2168078 | - | 381 | WP_220360761.1 | hypothetical protein | - |
| JMO12_RS10870 (JMO12_002176) | 2168388..2170097 | - | 1710 | WP_000447473.1 | DUF927 domain-containing protein | - |
| JMO12_RS10875 (JMO12_002177) | 2170111..2170980 | - | 870 | WP_001002689.1 | primase alpha helix C-terminal domain-containing protein | - |
| JMO12_RS10880 (JMO12_002178) | 2171045..2171371 | - | 327 | WP_001078344.1 | DUF1474 family protein | Toxin |
| JMO12_RS10885 (JMO12_002179) | 2171374..2171583 | - | 210 | WP_001058495.1 | hypothetical protein | Antitoxin |
| JMO12_RS10890 (JMO12_002180) | 2171576..2171722 | - | 147 | WP_000784885.1 | hypothetical protein | - |
| JMO12_RS10895 (JMO12_002181) | 2171719..2172036 | - | 318 | WP_000481967.1 | helix-turn-helix domain-containing protein | - |
| JMO12_RS10900 (JMO12_002182) | 2172041..2172259 | - | 219 | WP_000153640.1 | helix-turn-helix transcriptional regulator | - |
| JMO12_RS10905 (JMO12_002183) | 2172432..2173106 | + | 675 | WP_000620857.1 | helix-turn-helix transcriptional regulator | - |
| JMO12_RS10910 (JMO12_002184) | 2173120..2174292 | + | 1173 | WP_000179343.1 | tyrosine-type recombinase/integrase | - |
| JMO12_RS10915 (JMO12_002185) | 2174361..2175977 | - | 1617 | WP_000240642.1 | chaperonin GroEL | - |
| JMO12_RS10920 (JMO12_002186) | 2176053..2176337 | - | 285 | WP_000917289.1 | co-chaperone GroES | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | sell / sec / tsst-1 / groEL | 2156855..2176337 | 19482 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 109 a.a. Molecular weight: 12968.26 Da Isoelectric Point: 4.3050
>T212078 WP_001078344.1 NZ_CP080552:c2171371-2171045 [Staphylococcus aureus]
MNREIKDLFSDLKLLKDSFEDLKDSNGWHFDELYPYEPNHVLNKDELIGEGFSYHERRIHNNQMFDLFHLYIEQFDNIIE
KFYEIEKASSENFGEESDDAKNSIKVAE
MNREIKDLFSDLKLLKDSFEDLKDSNGWHFDELYPYEPNHVLNKDELIGEGFSYHERRIHNNQMFDLFHLYIEQFDNIIE
KFYEIEKASSENFGEESDDAKNSIKVAE
Download Length: 327 bp
>T212078 NZ_CP106929:2323532-2323846 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA
Antitoxin
Download Length: 70 a.a. Molecular weight: 8206.22 Da Isoelectric Point: 4.3718
>AT212078 WP_001058495.1 NZ_CP080552:c2171583-2171374 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVVNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE
MNNEQKEVIEHVVYQLELSVVNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE
Download Length: 210 bp
>AT212078 NZ_CP106929:2323843-2324259 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3K0C1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3JSN0 |