Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 878329..878806 Replicon chromosome
Accession NZ_CP080552
Organism Staphylococcus aureus strain HL18807

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag JMO12_RS04135 Protein ID WP_000052076.1
Coordinates 878329..878517 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag JMO12_RS04140 Protein ID WP_001059690.1
Coordinates 878546..878806 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMO12_RS04105 (JMO12_000823) 874323..874844 + 522 WP_000824482.1 hypothetical protein -
JMO12_RS04110 (JMO12_000824) 875185..875871 + 687 WP_000141557.1 thermonuclease family protein -
JMO12_RS04115 (JMO12_000825) 876228..876428 + 201 WP_001059082.1 cold-shock protein -
JMO12_RS04120 (JMO12_000826) 876920..877138 - 219 WP_000005886.1 hypothetical protein -
JMO12_RS04125 (JMO12_000827) 877200..877484 - 285 WP_044423470.1 hypothetical protein -
JMO12_RS04130 (JMO12_000828) 877572..878141 - 570 WP_001106654.1 lipoprotein N-acylation protein LnsA -
JMO12_RS04135 (JMO12_000829) 878329..878517 - 189 WP_000052076.1 hypothetical protein Toxin
JMO12_RS04140 (JMO12_000830) 878546..878806 - 261 WP_001059690.1 hypothetical protein Antitoxin
JMO12_RS04145 (JMO12_000831) 879147..879350 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
JMO12_RS04150 (JMO12_000832) 879347..879583 - 237 WP_063456452.1 hypothetical protein -
JMO12_RS04155 (JMO12_000833) 879808..880389 + 582 WP_001140693.1 histidine phosphatase family protein -
JMO12_RS04160 (JMO12_000834) 880462..881079 - 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
JMO12_RS04165 (JMO12_000835) 881234..881728 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
JMO12_RS04170 (JMO12_000836) 882127..882549 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
JMO12_RS04175 (JMO12_000837) 882697..883413 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T212071 WP_000052076.1 NZ_CP080552:c878517-878329 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T212071 NZ_CP106929:c997671-997568 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT212071 WP_001059690.1 NZ_CP080552:c878806-878546 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT212071 NZ_CP106929:997530-997801 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References