Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2141902..2142416 Replicon chromosome
Accession NZ_CP080551
Organism Staphylococcus aureus strain HL18840

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag JMO13_RS10610 Protein ID WP_000581792.1
Coordinates 2141902..2142111 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag JMO13_RS10615 Protein ID WP_000138932.1
Coordinates 2142123..2142416 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMO13_RS10590 (2137410) 2137410..2138768 - 1359 WP_000611470.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
JMO13_RS10595 (2138783) 2138783..2139853 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
JMO13_RS10600 (2140171) 2140171..2141373 + 1203 WP_020978293.1 FtsW/RodA/SpoVE family cell cycle protein -
JMO13_RS10605 (2141637) 2141637..2141774 - 138 WP_000828354.1 Lmo0850 family protein -
JMO13_RS10610 (2141902) 2141902..2142111 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
JMO13_RS10615 (2142123) 2142123..2142416 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
JMO13_RS10620 (2142582) 2142582..2144066 + 1485 WP_000571549.1 cardiolipin synthase -
JMO13_RS10625 (2144094) 2144094..2144741 + 648 WP_001187630.1 HD domain-containing protein -
JMO13_RS10630 (2145213) 2145213..2146085 - 873 WP_000725802.1 membrane protein insertase YidC -
JMO13_RS10635 (2146171) 2146171..2146812 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T212065 WP_000581792.1 NZ_CP080551:c2142111-2141902 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T212065 NZ_CP106929:c356721-356614 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT212065 WP_000138932.1 NZ_CP080551:c2142416-2142123 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT212065 NZ_CP106929:356769-356835 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References