Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 833451..833928 Replicon chromosome
Accession NZ_CP080551
Organism Staphylococcus aureus strain HL18840

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag JMO13_RS03940 Protein ID WP_000052076.1
Coordinates 833451..833639 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag JMO13_RS03945 Protein ID WP_001059690.1
Coordinates 833668..833928 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMO13_RS03910 (829441) 829441..829962 + 522 WP_000824484.1 hypothetical protein -
JMO13_RS03915 (830303) 830303..830989 + 687 WP_001792695.1 thermonuclease family protein -
JMO13_RS03920 (831346) 831346..831546 + 201 WP_001059082.1 cold-shock protein -
JMO13_RS03925 (832042) 832042..832260 - 219 WP_000005886.1 hypothetical protein -
JMO13_RS03930 (832322) 832322..832606 - 285 WP_001004395.1 hypothetical protein -
JMO13_RS03935 (832694) 832694..833263 - 570 WP_001106654.1 lipoprotein N-acylation protein LnsA -
JMO13_RS03940 (833451) 833451..833639 - 189 WP_000052076.1 hypothetical protein Toxin
JMO13_RS03945 (833668) 833668..833928 - 261 WP_001059690.1 hypothetical protein Antitoxin
JMO13_RS03950 (834269) 834269..834472 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
JMO13_RS03955 (834469) 834469..834705 - 237 WP_000368687.1 hypothetical protein -
JMO13_RS03960 (834930) 834930..835511 + 582 WP_001140693.1 histidine phosphatase family protein -
JMO13_RS03965 (835584) 835584..836201 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
JMO13_RS03970 (836356) 836356..836850 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
JMO13_RS03975 (837249) 837249..837671 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
JMO13_RS03980 (837819) 837819..838535 + 717 WP_000150012.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T212056 WP_000052076.1 NZ_CP080551:c833639-833451 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T212056 NZ_CP106924:2698397-2698504 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCATCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT212056 WP_001059690.1 NZ_CP080551:c833928-833668 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT212056 NZ_CP106924:c2698344-2698283 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References