Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 2617897..2618420 Replicon chromosome
Accession NZ_CP080550
Organism Staphylococcus aureus strain HL18883

Toxin (Protein)


Gene name relE Uniprot ID A0A3A5LQI3
Locus tag JMO14_RS13170 Protein ID WP_000074049.1
Coordinates 2617897..2618163 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag JMO14_RS13175 Protein ID WP_000587616.1
Coordinates 2618163..2618420 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMO14_RS13150 (JMO14_002632) 2613204..2614391 - 1188 WP_000026189.1 MFS transporter -
JMO14_RS13155 (JMO14_002633) 2614787..2615563 - 777 WP_000072149.1 iron export ABC transporter permease subunit FetB -
JMO14_RS13160 (JMO14_002634) 2615556..2616218 - 663 WP_000923526.1 ATP-binding cassette domain-containing protein -
JMO14_RS13165 (JMO14_002635) 2616466..2617542 - 1077 WP_001076673.1 M42 family metallopeptidase -
JMO14_RS13170 (JMO14_002636) 2617897..2618163 - 267 WP_000074049.1 Txe/YoeB family addiction module toxin Toxin
JMO14_RS13175 (JMO14_002637) 2618163..2618420 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JMO14_RS13180 (JMO14_002638) 2618779..2619234 + 456 WP_000732076.1 DUF1307 domain-containing protein -
JMO14_RS13185 (JMO14_002639) 2619402..2620979 - 1578 WP_000143494.1 FMN-binding glutamate synthase family protein -
JMO14_RS13190 (JMO14_002640) 2621174..2621923 + 750 WP_000072461.1 CPBP family lipoprotein N-acylation protein LnsB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10676.24 Da        Isoelectric Point: 10.1597

>T212055 WP_000074049.1 NZ_CP080550:c2618163-2617897 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLRKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T212055 NZ_CP106924:2697861-2697968 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT212055 WP_000587616.1 NZ_CP080550:c2618420-2618163 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT212055 NZ_CP106924:c2697814-2697748 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A5LQI3

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References