212051

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2244543..2245057 Replicon chromosome
Accession NZ_CP080550
Organism Staphylococcus aureus strain HL18883

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag JMO14_RS11235 Protein ID WP_000581792.1
Coordinates 2244543..2244752 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag JMO14_RS11240 Protein ID WP_000138932.1
Coordinates 2244764..2245057 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMO14_RS11215 (JMO14_002245) 2240051..2241409 - 1359 WP_000611464.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
JMO14_RS11220 (JMO14_002246) 2241424..2242494 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
JMO14_RS11225 (JMO14_002247) 2242812..2244014 + 1203 WP_044425300.1 FtsW/RodA/SpoVE family cell cycle protein -
JMO14_RS11230 (JMO14_002248) 2244278..2244415 - 138 WP_000828354.1 Lmo0850 family protein -
JMO14_RS11235 (JMO14_002249) 2244543..2244752 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
JMO14_RS11240 (JMO14_002250) 2244764..2245057 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
JMO14_RS11245 (JMO14_002251) 2245223..2246707 + 1485 WP_000571549.1 cardiolipin synthase -
JMO14_RS11250 (JMO14_002252) 2246735..2247382 + 648 WP_001187630.1 HD domain-containing protein -
JMO14_RS11255 (JMO14_002253) 2247995..2248867 - 873 WP_000725802.1 membrane protein insertase YidC -
JMO14_RS11260 (JMO14_002254) 2248953..2249594 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T212051 WP_000581792.1 NZ_CP080550:c2244752-2244543 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T212051 NZ_CP106924:c1823877-1823503 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCATTACAGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGCGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCCA
CAACTACAGAACGGTGAACAATATCACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT212051 WP_000138932.1 NZ_CP080550:c2245057-2244764 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT212051 NZ_CP106924:c1824335-1823967 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References