Detailed information of TA system TA212042

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 879879..880356
• Replicon: chromosome
• Accession: NZ_CP080550
• Organism: Staphylococcus aureus strain HL18883

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: JMO14_RS04140
• Protein ID: WP_000052076.1
• Coordinates: 879879..880067 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: JMO14_RS04145
• Protein ID: WP_001059690.1
• Coordinates: 880096..880356 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMO14_RS04110 (JMO14_000823)	875873..876394	+	522	WP_000824482.1	hypothetical protein	-
JMO14_RS04115 (JMO14_000824)	876735..877421	+	687	WP_000141557.1	thermonuclease family protein	-
JMO14_RS04120 (JMO14_000825)	877778..877978	+	201	WP_001059082.1	cold-shock protein	-
JMO14_RS04125 (JMO14_000826)	878470..878688	-	219	WP_000005886.1	hypothetical protein	-
JMO14_RS04130 (JMO14_000827)	878750..879034	-	285	WP_044423470.1	hypothetical protein	-
JMO14_RS04135 (JMO14_000828)	879122..879691	-	570	WP_001106654.1	lipoprotein N-acylation protein LnsA	-
JMO14_RS04140 (JMO14_000829)	879879..880067	-	189	WP_000052076.1	hypothetical protein	Toxin
JMO14_RS04145 (JMO14_000830)	880096..880356	-	261	WP_001059690.1	hypothetical protein	Antitoxin
JMO14_RS04150 (JMO14_000831)	880697..880900	+	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
JMO14_RS04155 (JMO14_000832)	880897..881133	-	237	WP_063456452.1	hypothetical protein	-
JMO14_RS04160 (JMO14_000833)	881358..881939	+	582	WP_001140693.1	histidine phosphatase family protein	-
JMO14_RS04165 (JMO14_000834)	882012..882629	-	618	WP_000255551.1	LysE/ArgO family amino acid transporter	-
JMO14_RS04170 (JMO14_000835)	882784..883278	-	495	WP_000569884.1	GNAT family N-acetyltransferase	-
JMO14_RS04175 (JMO14_000836)	883677..884099	-	423	WP_000974460.1	organic hydroperoxide resistance protein	-
JMO14_RS04180 (JMO14_000837)	884247..884963	+	717	WP_000150011.1	type I 3-dehydroquinate dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	vWbp	861997..961801	99804

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Virulence-associated protein D / CRISPR associated protein Cas2 (1-86)

Antitoxin

• Protein of unknown function DUF5397 (2-60)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T212042 WP_000052076.1 NZ_CP080550:c880067-879879 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T212042 NZ_CP106922:434-712 [Neisseria gonorrhoeae]
ATGTACGCGATTTCTTTTGATTTGGTGGTTGCCGATACCGCTCAAAACCATCCGAAAGGCATTTCCCAAGCCTACGCGGA
TATTGGATACACCCTGCGGAAATTCGGCTTTACCCGCATTCAGGGAAGTTTGTACACCTGCCAAAACGAAGATATGGCTA
ACCTGTTTTCAGCCATCAACGAGCTAAAAGCTCTGCCTTGGTTTCCGTCTTCTGTCCGCGATATTCGGGCGTTCCGCATT
GAGCAGTGGTCTGATTTCACAAGTCTTGTGAAGTCTTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT212042 WP_001059690.1 NZ_CP080550:c880356-880096 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT212042 NZ_CP106922:249-434 [Neisseria gonorrhoeae]
ATGCAAACCACTATCCCCACCGGTTCAATCCGCACCTTTGGCGATTACGGCGTGATGTACATCGTCGGCACGCCTGCCGA
ACAGCTTCCGGACGGCGATTGGCTCGTAAATATTGAACTGCCGGAAAGCGGCGAACACACGCAATACAAACTGTCCCACA
TCGTTCAAGACCCAAAGGCTGCCTAA

Structures

Toxin

• AlphaFold DB: A0A0E0VP18

Antitoxin

• AlphaFold DB: A0A0E0VN56