Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2108021..2108489 Replicon chromosome
Accession NC_007168
Organism Staphylococcus haemolyticus JCSC1435

Toxin (Protein)


Gene name TsaT Uniprot ID Q4L4Q4
Locus tag SH_RS10015 Protein ID WP_011276326.1
Coordinates 2108301..2108489 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID Q4L4Q5
Locus tag SH_RS10010 Protein ID WP_011276325.1
Coordinates 2108021..2108278 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SH_RS09975 2103197..2103922 - 726 WP_011276319.1 type I 3-dehydroquinate dehydratase -
SH_RS09980 2104085..2104507 + 423 WP_011276320.1 organic hydroperoxide resistance protein -
SH_RS09985 2104770..2105261 + 492 WP_011276321.1 GNAT family N-acetyltransferase -
SH_RS09990 2105393..2106010 + 618 WP_011276322.1 LysE/ArgO family amino acid transporter -
SH_RS09995 2106197..2106805 - 609 WP_011276323.1 phosphoglycerate mutase family protein -
SH_RS10000 2107033..2107275 + 243 WP_011276324.1 hypothetical protein -
SH_RS10005 2107267..2107470 - 204 WP_033079647.1 sterile alpha motif-like domain-containing protein -
SH_RS10010 2108021..2108278 + 258 WP_011276325.1 hypothetical protein Antitoxin
SH_RS10015 2108301..2108489 + 189 WP_011276326.1 hypothetical protein Toxin
SH_RS10020 2108607..2109188 + 582 WP_011276327.1 hypothetical protein -
SH_RS10025 2109236..2109472 - 237 WP_016931008.1 hypothetical protein -
SH_RS13050 2109642..2110389 + 748 Protein_1973 membrane lipoprotein lipid attachment site-containing protein -
SH_RS10040 2110458..2111066 - 609 WP_011276331.1 GNAT family N-acetyltransferase -
SH_RS10045 2111203..2111949 + 747 WP_011276332.1 poly-gamma-glutamate hydrolase family protein -
SH_RS10050 2112025..2112312 + 288 WP_011276333.1 hypothetical protein -
SH_RS10055 2112558..2112782 + 225 WP_011276334.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Entericidin A/B

(23-42)

Antitoxin

Entericidin A/B

(23-42)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7110.80 Da        Isoelectric Point: 9.6269

>T21204 WP_011276326.1 NC_007168:2108301-2108489 [Staphylococcus haemolyticus JCSC1435]
MSLHLTILLWLGIIFVIAASIILGLLLKSKKEERKESYLGFTVIFYIFGFALLIYVFIFGIL

Download         Length: 189 bp

>T21204 NC_007168:2108301-2108489 [Staphylococcus haemolyticus JCSC1435]
ATGAGTTTGCATTTAACTATATTGTTATGGCTTGGTATCATTTTTGTAATAGCAGCCTCAATTATATTGGGCTTATTACT
TAAATCTAAAAAAGAAGAACGTAAAGAATCATATTTAGGTTTTACCGTAATATTTTATATTTTTGGATTTGCTTTACTCA
TCTACGTATTCATATTTGGTATATTATAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9914.97 Da        Isoelectric Point: 4.0625

>AT21204 WP_011276325.1 NC_007168:2108021-2108278 [Staphylococcus haemolyticus JCSC1435]
MNNNKIFWINIFMTLLFLGFNIIVTYNADLDDFFWLIPGLTISGITIVLSLSTALICKNLVSEVIFLINIVMLLYYIYPM
VYTFF

Download         Length: 258 bp

>AT21204 NC_007168:2108021-2108278 [Staphylococcus haemolyticus JCSC1435]
ATGAATAATAATAAAATTTTTTGGATAAATATTTTTATGACGCTATTATTTTTGGGTTTCAATATCATTGTCACTTACAA
TGCAGACTTAGATGATTTCTTCTGGCTAATTCCAGGACTGACAATTAGTGGTATCACAATTGTACTAAGCTTAAGTACTG
CGCTCATTTGCAAGAACCTGGTTAGCGAAGTTATTTTTCTAATCAATATTGTTATGCTTTTATACTACATTTATCCTATG
GTATATACATTCTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A1KAB5

Antitoxin

Source ID Structure
AlphaFold DB A0A2A1KAX9

References