Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2211333..2211862 Replicon chromosome
Accession NZ_CP080548
Organism Staphylococcus aureus strain HL18888

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag JMO15_RS11055 Protein ID WP_000621175.1
Coordinates 2211333..2211695 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag JMO15_RS11060 Protein ID WP_000948331.1
Coordinates 2211692..2211862 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMO15_RS11035 (2208312) 2208312..2209082 - 771 WP_001041111.1 RNA polymerase sigma factor SigB -
JMO15_RS11040 (2209057) 2209057..2209536 - 480 WP_001190829.1 anti-sigma B factor RsbW -
JMO15_RS11045 (2209538) 2209538..2209864 - 327 WP_001052491.1 anti-sigma factor antagonist -
JMO15_RS11050 (2209983) 2209983..2210984 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
JMO15_RS11055 (2211333) 2211333..2211695 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JMO15_RS11060 (2211692) 2211692..2211862 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
JMO15_RS11065 (2211947) 2211947..2213095 - 1149 WP_001281154.1 alanine racemase -
JMO15_RS11070 (2213161) 2213161..2213520 - 360 WP_000581197.1 holo-ACP synthase -
JMO15_RS11075 (2213524) 2213524..2214015 - 492 WP_001205912.1 PH domain-containing protein -
JMO15_RS11080 (2214002) 2214002..2215585 - 1584 WP_001294626.1 PH domain-containing protein -
JMO15_RS11085 (2215578) 2215578..2216057 - 480 WP_001287087.1 hypothetical protein -
JMO15_RS11090 (2216265) 2216265..2216825 - 561 WP_001092411.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T212034 WP_000621175.1 NZ_CP080548:c2211695-2211333 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

>T212034 NZ_CP106915:63020-63169 [Klebsiella pneumoniae]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT212034 WP_000948331.1 NZ_CP080548:c2211862-2211692 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT212034 NZ_CP106915:c62975-62916 [Klebsiella pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References