Detailed information of TA system TA212033

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 2159424..2159938
• Replicon: chromosome
• Accession: NZ_CP080548
• Organism: Staphylococcus aureus strain HL18888

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: A0A0H3K0C1
• Locus tag: JMO15_RS10785
• Protein ID: WP_001078344.1
• Coordinates: 2159424..2159750 (-)
• Length: 109 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: JMO15_RS10790
• Protein ID: WP_223200634.1
• Coordinates: 2159753..2159938 (-)
• Length: 62 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMO15_RS10760 (2154648)	2154648..2154989	-	342	WP_001190615.1	hypothetical protein	-
JMO15_RS10765 (2155439)	2155439..2156080	-	642	WP_063663566.1	pathogenicity island protein	-
JMO15_RS10770 (2156077)	2156077..2156457	-	381	WP_000356942.1	hypothetical protein	-
JMO15_RS10775 (2156767)	2156767..2158476	-	1710	WP_138936772.1	DUF927 domain-containing protein	-
JMO15_RS10780 (2158490)	2158490..2159359	-	870	WP_001002689.1	primase alpha helix C-terminal domain-containing protein	-
JMO15_RS10785 (2159424)	2159424..2159750	-	327	WP_001078344.1	DUF1474 family protein	Toxin
JMO15_RS10790 (2159753)	2159753..2159938	-	186	WP_223200634.1	pathogenicity island protein	Antitoxin
JMO15_RS10795 (2159955)	2159955..2160101	-	147	WP_000784885.1	hypothetical protein	-
JMO15_RS10800 (2160098)	2160098..2160415	-	318	WP_000481967.1	helix-turn-helix domain-containing protein	-
JMO15_RS10805 (2160420)	2160420..2160638	-	219	WP_000153640.1	helix-turn-helix transcriptional regulator	-
JMO15_RS10810 (2160811)	2160811..2161485	+	675	WP_000620857.1	helix-turn-helix transcriptional regulator	-
JMO15_RS10815 (2161499)	2161499..2162671	+	1173	WP_000179343.1	tyrosine-type recombinase/integrase	-
JMO15_RS10820 (2162740)	2162740..2164356	-	1617	WP_000240642.1	chaperonin GroEL	-
JMO15_RS10825 (2164432)	2164432..2164716	-	285	WP_000917289.1	co-chaperone GroES	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / see / tsst-1 / groEL	2142393..2164716	22323

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-100)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 109 a.a.
• Molecular weight: 12968.26 Da
• Isoelectric Point: 4.3050

>T212033 WP_001078344.1 NZ_CP080548:c2159750-2159424 [Staphylococcus aureus]
MNREIKDLFSDLKLLKDSFEDLKDSNGWHFDELYPYEPNHVLNKDELIGEGFSYHERRIHNNQMFDLFHLYIEQFDNIIE
KFYEIEKASSENFGEESDDAKNSIKVAE

Nucleotide

• Length: 327 bp

>T212033 NZ_CP106915:c17599-17183 [Klebsiella pneumoniae]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin

Protein

• Length: 62 a.a.
• Molecular weight: 7233.15 Da
• Isoelectric Point: 4.4184

>AT212033 WP_223200634.1 NZ_CP080548:c2159938-2159753 [Staphylococcus aureus]
IEHVVYQLELSVVNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 186 bp

>AT212033 NZ_CP106915:c17826-17596 [Klebsiella pneumoniae]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA

Structures

Toxin

• AlphaFold DB: A0A0H3K0C1