Detailed information of TA system TA021203

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1116547..1117318
• Replicon: chromosome
• Accession: NC_007168
• Organism: Staphylococcus haemolyticus JCSC1435

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: SH_RS13770
• Protein ID: WP_011275410.1
• Coordinates: 1117169..1117318 (+)
• Length: 50 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: Q4L7F8
• Locus tag: SH_RS05385
• Protein ID: WP_011275409.1
• Coordinates: 1116547..1117146 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SH_RS05365	1112430..1113884	+	1455	WP_011275405.1	ABC transporter substrate-binding protein/permease	-
SH_RS05370	1113877..1114599	+	723	WP_011275406.1	amino acid ABC transporter ATP-binding protein	-
SH_RS05375	1114777..1115904	+	1128	WP_011275407.1	tRNA epoxyqueuosine(34) reductase QueG	-
SH_RS05380	1115905..1116375	+	471	WP_011275408.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
SH_RS05385	1116547..1117146	+	600	WP_011275409.1	glucosamine-6-phosphate isomerase	Antitoxin
SH_RS13770	1117169..1117318	+	150	WP_011275410.1	hypothetical protein	Toxin
SH_RS05390	1117529..1117924	+	396	WP_011275411.1	hypothetical protein	-
SH_RS05395	1118131..1119516	+	1386	WP_011275412.1	class II fumarate hydratase	-
SH_RS05400	1119582..1120406	-	825	WP_011275413.1	RluA family pseudouridine synthase	-
SH_RS05405	1120594..1121703	+	1110	WP_011275414.1	GAF domain-containing sensor histidine kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	SCCmec	-	groEL / gnd	952510..1467007	514497

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (130-195)

Sequences

Toxin

Protein

• Length: 50 a.a.
• Molecular weight: 5796.18 Da
• Isoelectric Point: 3.9484

>T21203 WP_011275410.1 NC_007168:1117169-1117318 [Staphylococcus haemolyticus JCSC1435]
MTKNKDSELNYHEEENAMVQDLDDLKTLGKEMEQISEENDEDKLNQSHE

Nucleotide

• Length: 150 bp

>T21203 NC_007168:1117169-1117318 [Staphylococcus haemolyticus JCSC1435]
ATGACTAAAAATAAAGATTCAGAATTAAATTATCATGAGGAAGAAAATGCGATGGTTCAAGATTTAGATGACTTGAAAAC
CTTGGGTAAAGAAATGGAACAAATTTCTGAAGAAAACGACGAGGACAAGTTGAATCAATCGCATGAGTAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22272.12 Da
• Isoelectric Point: 4.7588

>AT21203 WP_011275409.1 NC_007168:1116547-1117146 [Staphylococcus haemolyticus JCSC1435]
MAMNFKVFNDVEHVAEYTADIIRKQFNNNPTTIAGIHLTKDAAPVLDELKKDVDHNAVDFSQVNILDYDDNRSYYEALGV
PASQIYPINLDDDAESLIDDKIKTKENKGKLILQVTSIDESGSLNVNVRQGLLKAREVVLVVTGANKREVVKKLYEENGK
SSFEPSDLKAHRMVTVVLDRAAAEGLPEDVKEYFTARFA

Nucleotide

• Length: 600 bp

>AT21203 NC_007168:1116547-1117146 [Staphylococcus haemolyticus JCSC1435]
ATGGCAATGAACTTTAAAGTATTTAATGATGTAGAACATGTAGCTGAGTACACAGCAGATATCATTAGAAAGCAATTTAA
TAATAACCCTACAACTATTGCGGGAATTCATTTAACAAAGGATGCTGCACCTGTTTTAGATGAGTTAAAGAAAGATGTAG
ATCATAATGCGGTTGATTTTAGTCAAGTAAATATCTTAGATTATGACGATAATCGCTCTTACTATGAAGCATTAGGTGTA
CCTGCTAGTCAAATTTATCCAATTAATCTTGACGATGATGCAGAATCTTTAATTGATGACAAAATTAAAACTAAAGAAAA
TAAAGGTAAATTAATTTTACAAGTTACTTCTATTGATGAATCAGGTAGTTTAAATGTAAATGTAAGACAAGGATTATTAA
AAGCGCGTGAAGTAGTATTAGTTGTGACTGGTGCTAATAAACGTGAAGTTGTTAAAAAACTTTATGAAGAAAATGGTAAA
TCTAGCTTTGAACCATCTGATTTAAAAGCTCATAGAATGGTAACAGTTGTTTTAGATAGAGCAGCTGCAGAAGGTTTACC
TGAGGATGTTAAAGAATATTTCACTGCTAGATTTGCTTAA

Structures

Antitoxin

• AlphaFold DB: A0A2A1K9C2