212025

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 884536..885013 Replicon chromosome
Accession NZ_CP080548
Organism Staphylococcus aureus strain HL18888

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag JMO15_RS04230 Protein ID WP_000052076.1
Coordinates 884536..884724 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag JMO15_RS04235 Protein ID WP_001059690.1
Coordinates 884753..885013 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMO15_RS04200 (880530) 880530..881051 + 522 WP_000824482.1 hypothetical protein -
JMO15_RS04205 (881392) 881392..882078 + 687 WP_000141557.1 thermonuclease family protein -
JMO15_RS04210 (882435) 882435..882635 + 201 WP_001059082.1 cold-shock protein -
JMO15_RS04215 (883127) 883127..883345 - 219 WP_000005886.1 hypothetical protein -
JMO15_RS04220 (883407) 883407..883691 - 285 WP_001004399.1 hypothetical protein -
JMO15_RS04225 (883779) 883779..884348 - 570 WP_001106654.1 lipoprotein N-acylation protein LnsA -
JMO15_RS04230 (884536) 884536..884724 - 189 WP_000052076.1 hypothetical protein Toxin
JMO15_RS04235 (884753) 884753..885013 - 261 WP_001059690.1 hypothetical protein Antitoxin
JMO15_RS04240 (885354) 885354..885557 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
JMO15_RS04245 (885554) 885554..885790 - 237 WP_000349581.1 hypothetical protein -
JMO15_RS04250 (886015) 886015..886596 + 582 WP_001140693.1 histidine phosphatase family protein -
JMO15_RS04255 (886669) 886669..887286 - 618 WP_063663419.1 LysE/ArgO family amino acid transporter -
JMO15_RS04260 (887441) 887441..887935 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
JMO15_RS04265 (888334) 888334..888756 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
JMO15_RS04270 (888904) 888904..889620 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T212025 WP_000052076.1 NZ_CP080548:c884724-884536 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T212025 NZ_CP106912:c4814235-4813702 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT212025 WP_001059690.1 NZ_CP080548:c885013-884753 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT212025 NZ_CP106912:c4814512-4814246 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References