Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 856618..857147 Replicon chromosome
Accession NZ_CP080548
Organism Staphylococcus aureus strain HL18888

Toxin (Protein)


Gene name TscT Uniprot ID K7ZRX2
Locus tag JMO15_RS04070 Protein ID WP_001103933.1
Coordinates 856830..857147 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID A0A6B0BJC0
Locus tag JMO15_RS04065 Protein ID WP_001058487.1
Coordinates 856618..856827 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMO15_RS04030 (853069) 853069..853533 + 465 WP_001085183.1 SsrA-binding protein SmpB -
JMO15_RS04040 (854096) 854096..855202 - 1107 WP_000121223.1 tyrosine-type recombinase/integrase -
JMO15_RS04045 (855208) 855208..855825 - 618 WP_223200480.1 helix-turn-helix transcriptional regulator -
JMO15_RS04050 (856013) 856013..856219 + 207 WP_001060953.1 hypothetical protein -
JMO15_RS04055 (856255) 856255..856482 + 228 WP_000164237.1 helix-turn-helix transcriptional regulator -
JMO15_RS04060 (856479) 856479..856625 + 147 WP_000784893.1 hypothetical protein -
JMO15_RS04065 (856618) 856618..856827 + 210 WP_001058487.1 hypothetical protein Antitoxin
JMO15_RS04070 (856830) 856830..857147 + 318 WP_001103933.1 DUF1474 family protein Toxin
JMO15_RS04075 (857214) 857214..858083 + 870 WP_220369835.1 primase alpha helix C-terminal domain-containing protein -
JMO15_RS04080 (858100) 858100..859569 + 1470 WP_001668899.1 virulence-associated E family protein -
JMO15_RS04085 (859855) 859855..860217 + 363 WP_001039169.1 hypothetical protein -
JMO15_RS04090 (860219) 860219..860503 + 285 WP_000998179.1 hypothetical protein -
JMO15_RS04095 (860500) 860500..861141 + 642 WP_063663413.1 pathogenicity island protein -
JMO15_RS04100 (861591) 861591..861932 + 342 WP_001190615.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 850675..865910 15235


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-98)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12511.13 Da        Isoelectric Point: 4.6364

>T212024 WP_001103933.1 NZ_CP080548:856830-857147 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKEKINDVAIKHGWFVEDKFVKNELETKQEHINFSASYLEHRIQNEHTVELLQVYLKEFGELIQKF
HEIEKASSENFGEESDDAKKLKITE

Download         Length: 318 bp

>T212024 NZ_CP106912:4201538-4201756 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8228.24 Da        Isoelectric Point: 4.1682

>AT212024 WP_001058487.1 NZ_CP080548:856618-856827 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSIMNNFESYEHTEYVDGIEVVSEISPEKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT212024 NZ_CP106912:4201137-4201511 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K7ZRX2

Antitoxin

Source ID Structure
AlphaFold DB A0A6B0BJC0

References