Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 5156295..5156930 Replicon chromosome
Accession NZ_CP080545
Organism Paenibacillus sp. sptzw28

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag KZ483_RS23760 Protein ID WP_189000789.1
Coordinates 5156295..5156645 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag KZ483_RS23765 Protein ID WP_220350033.1
Coordinates 5156649..5156930 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZ483_RS23740 (KZ483_23740) 5152424..5153266 - 843 WP_258881397.1 hypothetical protein -
KZ483_RS23745 (KZ483_23745) 5153263..5153994 - 732 WP_220350030.1 SAF domain-containing protein -
KZ483_RS23750 (KZ483_23750) 5154163..5154765 - 603 WP_220350031.1 TetR family transcriptional regulator -
KZ483_RS23755 (KZ483_23755) 5154853..5156013 - 1161 WP_220350032.1 DUF3533 domain-containing protein -
KZ483_RS23760 (KZ483_23760) 5156295..5156645 - 351 WP_189000789.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
KZ483_RS23765 (KZ483_23765) 5156649..5156930 - 282 WP_220350033.1 ribbon-helix-helix protein, CopG family Antitoxin
KZ483_RS23770 (KZ483_23770) 5157159..5158334 - 1176 WP_220350034.1 alanine racemase -
KZ483_RS23775 (KZ483_23775) 5158524..5159777 - 1254 WP_220350035.1 DUF4367 domain-containing protein -
KZ483_RS23780 (KZ483_23780) 5160312..5160839 - 528 WP_220350036.1 putative metal-dependent hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-45)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12822.72 Da        Isoelectric Point: 5.1284

>T212023 WP_189000789.1 NZ_CP080545:c5156645-5156295 [Paenibacillus sp. sptzw28]
MIVKRGDVFFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAASHGFDRDSVILLEQI
RTIDKQRLTDKITHLDDETMRKVDESLQISVGLIDF

Download         Length: 351 bp

>T212023 NZ_CP106912:c2742539-2741217 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCTGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10623.24 Da        Isoelectric Point: 7.0153

>AT212023 WP_220350033.1 NZ_CP080545:c5156930-5156649 [Paenibacillus sp. sptzw28]
VTNLQNTKRIMISLPDHLLEEVDGIVAKENSNRSEFIRQAMKLYLVERKKRQIRESMQRGYLEMAKINLVMASEAFQAEE
DAGDTLGRLVSGV

Download         Length: 282 bp

>AT212023 NZ_CP106912:c2742805-2742539 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References