212022

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2275891..2276555 Replicon chromosome
Accession NZ_CP080536
Organism Acidithiobacillus ferriphilus strain GT2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag K1Y48_RS11325 Protein ID WP_215850605.1
Coordinates 2275891..2276322 (-) Length 144 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag K1Y48_RS11330 Protein ID WP_081258033.1
Coordinates 2276322..2276555 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K1Y48_RS11295 (K1Y48_11325) 2271352..2272035 + 684 WP_229066089.1 hypothetical protein -
K1Y48_RS11300 (K1Y48_11330) 2272002..2273411 - 1410 WP_229066091.1 2-isopropylmalate synthase -
K1Y48_RS11305 (K1Y48_11335) 2273553..2274038 + 486 WP_215850601.1 Lrp/AsnC family transcriptional regulator -
K1Y48_RS11310 (K1Y48_11340) 2274096..2274563 - 468 WP_215879526.1 MarR family transcriptional regulator -
K1Y48_RS11315 (K1Y48_11345) 2274631..2275110 + 480 WP_215850603.1 carboxymuconolactone decarboxylase family protein -
K1Y48_RS11320 (K1Y48_11350) 2275107..2275586 + 480 WP_215850604.1 GNAT family N-acetyltransferase -
K1Y48_RS11325 (K1Y48_11355) 2275891..2276322 - 432 WP_215850605.1 VapC toxin family PIN domain ribonuclease Toxin
K1Y48_RS11330 (K1Y48_11360) 2276322..2276555 - 234 WP_081258033.1 CopG family transcriptional regulator Antitoxin
K1Y48_RS11335 (K1Y48_11365) 2276824..2277348 + 525 WP_215850606.1 methylated-DNA--[protein]-cysteine S-methyltransferase -
K1Y48_RS11340 (K1Y48_11370) 2277345..2278814 - 1470 WP_215859824.1 DNA-3-methyladenine glycosylase 2 -
K1Y48_RS11345 (K1Y48_11375) 2278921..2281302 - 2382 WP_215848987.1 sucrose synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-127)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 144 a.a.        Molecular weight: 15668.02 Da        Isoelectric Point: 6.3937

>T212022 WP_215850605.1 NZ_CP080536:c2276322-2275891 [Acidithiobacillus ferriphilus]
MIFLLDVNVLIALIDPMHVQHDMAHEWFAAHGQPAWATCPLTENAVLRIVGHPRYPNSPGTPAAVAPLIQGLRASPGHVF
WPDDISLLDVDHIDASRLLTSGQITDSYLLALACAHEGQLATFDHRLVTNAVRNGLQCINKIR

Download         Length: 432 bp

>T212022 NZ_CP106912:2012309-2012411 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8172.36 Da        Isoelectric Point: 7.2027

>AT212022 WP_081258033.1 NZ_CP080536:c2276555-2276322 [Acidithiobacillus ferriphilus]
MRTTLAIDDDVLAAAKGLADRQHKPVGAVVSALLRQALQSQNTSGGHSRNGIPLLPVRPDALPATLEIVNQLRDELP

Download         Length: 234 bp

>AT212022 NZ_CP106912:c2012418-2012273 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References