212021

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapB(antitoxin)
Location 2113601..2114169 Replicon chromosome
Accession NZ_CP080536
Organism Acidithiobacillus ferriphilus strain GT2

Toxin (Protein)


Gene name vapC Uniprot ID A0A179BKY0
Locus tag K1Y48_RS10540 Protein ID WP_064218579.1
Coordinates 2113601..2113975 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A179BJW8
Locus tag K1Y48_RS10545 Protein ID WP_064218578.1
Coordinates 2113972..2114169 (-) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K1Y48_RS10515 (K1Y48_10545) 2108988..2109695 - 708 WP_215850395.1 bifunctional 2-polyprenyl-6-hydroxyphenol methylase/3-demethylubiquinol 3-O-methyltransferase UbiG -
K1Y48_RS10520 (K1Y48_10550) 2109692..2111038 - 1347 WP_229066038.1 TRZ/ATZ family hydrolase -
K1Y48_RS10525 (K1Y48_10555) 2111136..2112305 - 1170 WP_215850394.1 lytic murein transglycosylase -
K1Y48_RS10530 (K1Y48_10560) 2112306..2112884 - 579 WP_215880173.1 C40 family peptidase -
K1Y48_RS10540 (K1Y48_10570) 2113601..2113975 - 375 WP_064218579.1 type II toxin-antitoxin system VapC family toxin Toxin
K1Y48_RS10545 (K1Y48_10575) 2113972..2114169 - 198 WP_064218578.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
K1Y48_RS10550 (K1Y48_10580) 2114959..2115537 - 579 WP_064218577.1 cytochrome b/b6 domain-containing protein -
K1Y48_RS10555 (K1Y48_10585) 2115569..2116966 - 1398 WP_215850392.1 MFS transporter -
K1Y48_RS10560 (K1Y48_10590) 2117423..2118808 - 1386 WP_215850391.1 chloride channel protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-109)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-46)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13773.74 Da        Isoelectric Point: 5.0809

>T212021 WP_064218579.1 NZ_CP080536:c2113975-2113601 [Acidithiobacillus ferriphilus]
MILVDTSVWIDHFRSGDTHLSTLLDHGMVQTHDFIIGEIACGNLKNRQQTLYLLSCLPRCTATSPEETLFFIERHDLMGR
GIGYVDASILASAVLVQANLWSRDKRLMALATELGCAYSAESSE

Download         Length: 375 bp

>T212021 NZ_CP106912:878291-878698 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCGTGC
GCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCCGAA
TGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGGACA
GCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGGCGC
AGGAGTAA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7225.32 Da        Isoelectric Point: 9.4896

>AT212021 WP_064218578.1 NZ_CP080536:c2114169-2113972 [Acidithiobacillus ferriphilus]
MRTTINLDDDLLAQAKTLCGVEDRGALLKEALRALIERESARRLARLGGTEPQLQSIPRRREPAA

Download         Length: 198 bp

>AT212021 NZ_CP106912:878044-878310 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A179BKY0

Antitoxin

Source ID Structure
AlphaFold DB A0A179BJW8

References