Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapC-vagC/VapC-VagC |
| Location | 2051536..2052182 | Replicon | chromosome |
| Accession | NZ_CP080536 | ||
| Organism | Acidithiobacillus ferriphilus strain GT2 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | K1Y48_RS10250 | Protein ID | WP_229066493.1 |
| Coordinates | 2051536..2051919 (-) | Length | 128 a.a. |
Antitoxin (Protein)
| Gene name | vagC | Uniprot ID | A0A179BNW7 |
| Locus tag | K1Y48_RS10255 | Protein ID | WP_064218244.1 |
| Coordinates | 2051946..2052182 (-) | Length | 79 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K1Y48_RS10210 (K1Y48_10240) | 2046916..2047374 | - | 459 | WP_215849169.1 | hemerythrin domain-containing protein | - |
| K1Y48_RS10215 (K1Y48_10245) | 2047479..2047724 | + | 246 | WP_215849168.1 | thioredoxin family protein | - |
| K1Y48_RS10220 (K1Y48_10250) | 2047743..2048726 | - | 984 | WP_215849167.1 | FAD-binding oxidoreductase | - |
| K1Y48_RS10225 (K1Y48_10255) | 2048790..2049251 | - | 462 | WP_064218249.1 | globin domain-containing protein | - |
| K1Y48_RS10230 (K1Y48_10260) | 2049628..2050551 | + | 924 | WP_064218248.1 | LysR family transcriptional regulator | - |
| K1Y48_RS10235 (K1Y48_10265) | 2050548..2050817 | - | 270 | WP_064218247.1 | hypothetical protein | - |
| K1Y48_RS10240 (K1Y48_10270) | 2050879..2051103 | - | 225 | WP_215849166.1 | hypothetical protein | - |
| K1Y48_RS10245 (K1Y48_10275) | 2051308..2051466 | + | 159 | WP_215849165.1 | hypothetical protein | - |
| K1Y48_RS10250 (K1Y48_10280) | 2051536..2051919 | - | 384 | WP_229066493.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| K1Y48_RS10255 (K1Y48_10285) | 2051946..2052182 | - | 237 | WP_064218244.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| K1Y48_RS10260 (K1Y48_10290) | 2052845..2053645 | - | 801 | WP_215848789.1 | hypothetical protein | - |
| K1Y48_RS10265 (K1Y48_10295) | 2053818..2054348 | - | 531 | WP_215848790.1 | DedA family protein | - |
| K1Y48_RS10270 (K1Y48_10300) | 2054599..2057139 | - | 2541 | WP_215879539.1 | DNA mismatch repair protein MutS | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 2051536..2059849 | 8313 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 128 a.a. Molecular weight: 13728.74 Da Isoelectric Point: 5.1236
>T212020 WP_229066493.1 NZ_CP080536:c2051919-2051536 [Acidithiobacillus ferriphilus]
MCIYLIKHQPEKVAQRFAQCYVGDVVMSAITYAELEYGVAVSADPDRERANLAALTEDIPVIAFDAPAGVAYGPIRQATS
ESKRDTLDKLIAAHAVALGVTIVTNKTRDFAKYPGVMIENWLSSGAP
MCIYLIKHQPEKVAQRFAQCYVGDVVMSAITYAELEYGVAVSADPDRERANLAALTEDIPVIAFDAPAGVAYGPIRQATS
ESKRDTLDKLIAAHAVALGVTIVTNKTRDFAKYPGVMIENWLSSGAP
Download Length: 384 bp
>T212020 NZ_CP106912:742829-743314 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGCCCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGCCCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA
Antitoxin
Download Length: 79 a.a. Molecular weight: 8913.92 Da Isoelectric Point: 5.7066
>AT212020 WP_064218244.1 NZ_CP080536:c2052182-2051946 [Acidithiobacillus ferriphilus]
MHTTRVFKNGNSQAVRIPADLAYERSDIEVEIEREGDEIRIRPAHRPLAGVLSKFARFSPNFMADGRGDQEQTERDTL
MHTTRVFKNGNSQAVRIPADLAYERSDIEVEIEREGDEIRIRPAHRPLAGVLSKFARFSPNFMADGRGDQEQTERDTL
Download Length: 237 bp
>AT212020 NZ_CP106912:742539-742832 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|