Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 964299..964831 Replicon chromosome
Accession NC_007168
Organism Staphylococcus haemolyticus JCSC1435

Toxin (Protein)


Gene name mazF Uniprot ID Q4L7V3
Locus tag SH_RS04555 Protein ID WP_011275272.1
Coordinates 964466..964831 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q4L7V4
Locus tag SH_RS04550 Protein ID WP_011275271.1
Coordinates 964299..964469 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SH_RS04525 960085..960564 + 480 WP_011275266.1 PH domain-containing protein -
SH_RS04530 960557..962080 + 1524 WP_011275267.1 PH domain-containing protein -
SH_RS04535 962073..962600 + 528 WP_011275268.1 PH domain-containing protein -
SH_RS04540 962610..962969 + 360 WP_011275269.1 holo-ACP synthase -
SH_RS04545 963065..964213 + 1149 WP_011275270.1 alanine racemase -
SH_RS04550 964299..964469 + 171 WP_011275271.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
SH_RS04555 964466..964831 + 366 WP_011275272.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
SH_RS04560 965139..966140 + 1002 WP_011275273.1 PP2C family protein-serine/threonine phosphatase -
SH_RS04565 966239..966565 + 327 WP_011275274.1 anti-sigma factor antagonist -
SH_RS04570 966567..967046 + 480 WP_011275275.1 anti-sigma B factor RsbW -
SH_RS04575 967021..967791 + 771 WP_011275276.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside SCCmec - groEL / gnd 952510..1467007 514497


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13672.75 Da        Isoelectric Point: 8.4121

>T21202 WP_011275272.1 NC_007168:964466-964831 [Staphylococcus haemolyticus JCSC1435]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYRLDKDSVILLEQIR
TLDKKRLKEKLTYLSDEKMQEVDEALDISLGLHDEVKTQNT

Download         Length: 366 bp

>T21202 NC_007168:964466-964831 [Staphylococcus haemolyticus JCSC1435]
ATGATTAGAAGAGGCGATGTATATTTAGCTGATTTGTCACCAGTACAGGGCTCAGAACAAGGGGGAGTCAGACCTGTAGT
TATCATTCAAAACGATACTGGTAACAAATATAGTCCTACCGTAATCGTTGCTGCGATTACGGGAAGGATTAATAAAGCGA
AAATACCCACACATGTTGAAATCGAGAAAAAGAAATACAGACTTGATAAAGATTCAGTTATTCTACTCGAGCAAATTAGA
ACATTAGATAAAAAACGACTAAAAGAAAAATTAACATATCTATCTGATGAGAAAATGCAAGAAGTGGATGAAGCGTTAGA
CATTAGTCTAGGATTGCATGATGAAGTTAAAACGCAAAACACATAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6380.08 Da        Isoelectric Point: 4.0325

>AT21202 WP_011275271.1 NC_007168:964299-964469 [Staphylococcus haemolyticus JCSC1435]
MLTFNQNRSHSLEQSLKEGYAQMAELNLSLATEAFPLECEACDCNETYLISNYKSE

Download         Length: 171 bp

>AT21202 NC_007168:964299-964469 [Staphylococcus haemolyticus JCSC1435]
ATGCTTACTTTCAATCAAAATAGAAGTCACAGTCTTGAACAATCTTTAAAAGAAGGCTATGCACAAATGGCCGAATTAAA
TCTCTCCCTAGCGACAGAAGCTTTTCCTCTAGAATGCGAAGCTTGTGATTGCAACGAAACGTACCTTATTTCTAATTATA
AAAGTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A1KA75

Antitoxin

Source ID Structure
AlphaFold DB A0A2A1K7K7

References