Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 5143535..5144130 Replicon chromosome
Accession NZ_CP080531
Organism Mesorhizobium sp. AR02

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag DBIPINDM_RS29010 Protein ID WP_183461718.1
Coordinates 5143942..5144130 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag DBIPINDM_RS29005 Protein ID WP_258582407.1
Coordinates 5143535..5143936 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DBIPINDM_RS28975 (DBIPINDM_004829) 5138776..5139186 - 411 WP_258582403.1 YeeE/YedE family protein -
DBIPINDM_RS28980 (DBIPINDM_004830) 5139183..5139488 - 306 WP_258589369.1 sulfite-sensing transcriptional repressor BigR -
DBIPINDM_RS28985 (DBIPINDM_004831) 5139515..5140810 - 1296 WP_258589370.1 bifunctional sulfur transferase/dioxygenase Blh -
DBIPINDM_RS28990 (DBIPINDM_004832) 5140969..5141796 - 828 WP_258582404.1 helix-turn-helix transcriptional regulator -
DBIPINDM_RS28995 (DBIPINDM_004833) 5141897..5142781 + 885 WP_258582405.1 SDR family oxidoreductase -
DBIPINDM_RS29000 (DBIPINDM_004834) 5142800..5143498 - 699 WP_258582406.1 RibD family protein -
DBIPINDM_RS29005 (DBIPINDM_004835) 5143535..5143936 - 402 WP_258582407.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
DBIPINDM_RS29010 (DBIPINDM_004836) 5143942..5144130 - 189 WP_183461718.1 type II toxin-antitoxin system HicA family toxin Toxin
DBIPINDM_RS29015 (DBIPINDM_004837) 5144499..5145446 + 948 WP_096448447.1 substrate-binding domain-containing protein -
DBIPINDM_RS29020 (DBIPINDM_004838) 5145689..5147260 + 1572 WP_258582408.1 sugar ABC transporter ATP-binding protein -
DBIPINDM_RS29025 (DBIPINDM_004839) 5147257..5148270 + 1014 WP_258582409.1 ABC transporter permease -
DBIPINDM_RS29030 (DBIPINDM_004840) 5148470..5149048 - 579 WP_258582410.1 flagellar basal body-associated protein FliL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-124)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7071.17 Da        Isoelectric Point: 11.6118

>T212014 WP_183461718.1 NZ_CP080531:c5144130-5143942 [Mesorhizobium sp. AR02]
INSADIIRLLQADGWFEVARKGSHAQFKHRDKQGRVTVPHPKRDIPIGTLRSIEKQSGLKLR

Download         Length: 189 bp

>T212014 NZ_CP106908:58810-59280 [Klebsiella pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
TTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGGCAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAACTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14256.08 Da        Isoelectric Point: 4.3383

>AT212014 WP_258582407.1 NZ_CP080531:c5143936-5143535 [Mesorhizobium sp. AR02]
MKQYIGLIHKDAGSDFGVSFPDFPGVITAGKDLDDARVMAEEALTLHIEGLVEDGEAIPEPSSLEAVMADTDNRDGVAIL
VAARTEARKAVRINVTLPDDVLRRIDAFAEAHGYTRSGFLAKAAEKAMELESA

Download         Length: 402 bp

>AT212014 NZ_CP106908:58370-58813 [Klebsiella pneumoniae]
ATGAAAACATTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
CGTAGCGCTTCTGGGCCAAATCAATGAAGGCCTGGACGGGAAGGTGGCGAATCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCGACCACGTTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGGATTATCCGCGTCATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAAGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAGACAGGAGCGTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References