Detailed information of TA system TA212013

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 4492628..4493256
• Replicon: chromosome
• Accession: NZ_CP080531
• Organism: Mesorhizobium sp. AR02

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: DBIPINDM_RS25835
• Protein ID: WP_258581847.1
• Coordinates: 4492870..4493256 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: DBIPINDM_RS25830
• Protein ID: WP_258581846.1
• Coordinates: 4492628..4492873 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DBIPINDM_RS25795 (DBIPINDM_004201)	4487766..4488863	-	1098	WP_258581841.1	AbrB family transcriptional regulator	-
DBIPINDM_RS25800 (DBIPINDM_004202)	4489043..4489288	+	246	WP_095201961.1	type II toxin-antitoxin system ParD family antitoxin	-
DBIPINDM_RS25805 (DBIPINDM_004203)	4489306..4489605	+	300	WP_258581842.1	type II toxin-antitoxin system RelE/ParE family toxin	-
DBIPINDM_RS25810 (DBIPINDM_004204)	4489707..4490015	-	309	WP_183462547.1	putative quinol monooxygenase	-
DBIPINDM_RS25815 (DBIPINDM_004205)	4490080..4490859	-	780	WP_258581843.1	SDR family oxidoreductase	-
DBIPINDM_RS25820 (DBIPINDM_004206)	4490924..4491361	-	438	WP_258581844.1	DsrE family protein	-
DBIPINDM_RS25825 (DBIPINDM_004207)	4491458..4492561	+	1104	WP_258581845.1	hypothetical protein	-
DBIPINDM_RS25830 (DBIPINDM_004208)	4492628..4492873	+	246	WP_258581846.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
DBIPINDM_RS25835 (DBIPINDM_004209)	4492870..4493256	+	387	WP_258581847.1	type II toxin-antitoxin system VapC family toxin	Toxin
DBIPINDM_RS25840 (DBIPINDM_004210)	4493263..4494189	-	927	WP_258589343.1	cation diffusion facilitator family transporter	-
DBIPINDM_RS25845 (DBIPINDM_004211)	4494216..4496405	-	2190	WP_258581848.1	anthranilate synthase	-
DBIPINDM_RS25850 (DBIPINDM_004212)	4496501..4496695	-	195	WP_258581849.1	hypothetical protein	-
DBIPINDM_RS25855 (DBIPINDM_004213)	4496724..4497494	+	771	WP_258581850.1	isocitrate lyase/phosphoenolpyruvate mutase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-121)

Antitoxin

• SpoVT-AbrB domain (7-43)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14328.52 Da
• Isoelectric Point: 7.3173

>T212013 WP_258581847.1 NZ_CP080531:4492870-4493256 [Mesorhizobium sp. AR02]
VIYLLDTNAVIAVIKGDEGLLALLKQHTPQDFALSAIVLHELYYGAEKSQRKAENLTRIEALQFPVLEFDREDARHAGEI
RATLATLGTPIGPYDALIGGQARARNLTLVTRNVREFERIKALFVKTW

Nucleotide

• Length: 387 bp

>T212013 NZ_CP106908:19973-20416 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAACAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
TGGGCACGCTATCGCGGCCGGCGCCGTCCTAGTGACGAACAATGTGAGAGAGTTTGAGCGGGTGCCGGGTCTGGTGCTGG
AAGACTGGGTGAAGAAAGCCGCTCTCTGCAGGGTAATTTCTTGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9337.41 Da
• Isoelectric Point: 4.4720

>AT212013 WP_258581846.1 NZ_CP080531:4492628-4492873 [Mesorhizobium sp. AR02]
MDKAKVFWSGRSQAVRLPKEFRFETDEVSIRRHGQTVILEPLAQDWAWLDQVIGPVDNDFAEAALEHQDGQDRPALDDVF
K

Nucleotide

• Length: 246 bp

>AT212013 NZ_CP106908:19746-19976 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGCTCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA