Detailed information of TA system TA212012

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 2504836..2505509
• Replicon: chromosome
• Accession: NZ_CP080531
• Organism: Mesorhizobium sp. AR02

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: DBIPINDM_RS16155
• Protein ID: WP_258588173.1
• Coordinates: 2505087..2505509 (+)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: DBIPINDM_RS16150
• Protein ID: WP_258589288.1
• Coordinates: 2504836..2505090 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DBIPINDM_RS16120 (DBIPINDM_002279)	2499913..2500047	-	135	WP_008833937.1	50S ribosomal protein L34	-
DBIPINDM_RS16125 (DBIPINDM_002280)	2500328..2501815	+	1488	WP_258588169.1	HAMP domain-containing sensor histidine kinase	-
DBIPINDM_RS16135 (DBIPINDM_002282)	2502413..2502943	+	531	WP_258588170.1	dihydrofolate reductase family protein	-
DBIPINDM_RS16140 (DBIPINDM_002283)	2503156..2503914	+	759	WP_258588171.1	SDR family NAD(P)-dependent oxidoreductase	-
DBIPINDM_RS16145 (DBIPINDM_002284)	2503942..2504511	-	570	WP_258588172.1	TMEM175 family protein	-
DBIPINDM_RS16150 (DBIPINDM_002285)	2504836..2505090	+	255	WP_258589288.1	plasmid stabilization protein	Antitoxin
DBIPINDM_RS16155 (DBIPINDM_002286)	2505087..2505509	+	423	WP_258588173.1	type II toxin-antitoxin system VapC family toxin	Toxin
DBIPINDM_RS16160	2505541..2505978	+	438	WP_258588174.1	hypothetical protein	-
DBIPINDM_RS16165 (DBIPINDM_002288)	2505986..2506168	+	183	WP_258588175.1	hypothetical protein	-
DBIPINDM_RS16170 (DBIPINDM_002289)	2506183..2506884	-	702	WP_258588176.1	GntR family transcriptional regulator	-
DBIPINDM_RS16175 (DBIPINDM_002290)	2507101..2508141	+	1041	WP_258588177.1	ABC transporter substrate-binding protein	-
DBIPINDM_RS16180 (DBIPINDM_002291)	2508222..2509307	+	1086	WP_258588178.1	ABC transporter ATP-binding protein	-
DBIPINDM_RS16185 (DBIPINDM_002292)	2509304..2510230	+	927	WP_258588179.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-124)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 14891.05 Da
• Isoelectric Point: 4.8487

>T212012 WP_258588173.1 NZ_CP080531:2505087-2505509 [Mesorhizobium sp. AR02]
MIVLDTNIVSEAMKPEPAPAVRDWLDEQAAETLYLSSVTVAELLFGIGVLPDGRRKQNLATTLDGLLDLFDGRILPFDRD
AARRYADLAVAARNAGRGFPTPDGYIAAIAVAHGFVVATRDASAFKAAGVPVIAPWKAGQ

Nucleotide

• Length: 423 bp

>T212012 NZ_CP106907:124846-125262 [Klebsiella pneumoniae]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9277.45 Da
• Isoelectric Point: 7.3221

>AT212012 WP_258589288.1 NZ_CP080531:2504836-2505090 [Mesorhizobium sp. AR02]
MPAVTIRNLSEEAHRALKVRAAHHGRSTEAEMRELLEAAVRPANRIRIGSALSALSRNAGLTNADFEPLEQDRDRTPATP
MSFE

Nucleotide

• Length: 255 bp

>AT212012 NZ_CP106907:124619-124849 [Klebsiella pneumoniae]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA