Detailed information of TA system TA021201

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsdAT/-
• Location: 951374..951885
• Replicon: chromosome
• Accession: NC_007168
• Organism: Staphylococcus haemolyticus JCSC1435

Toxin (Protein)

• Gene name: TsdT
• Uniprot ID: Q4L7W7
• Locus tag: SH_RS04495
• Protein ID: WP_011275259.1
• Coordinates: 951679..951885 (+)
• Length: 69 a.a.

Antitoxin (Protein)

• Gene name: TsdA
• Uniprot ID: -
• Locus tag: SH_RS04490
• Protein ID: WP_011275258.1
• Coordinates: 951374..951667 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SH_RS04470	946591..947466	+	876	WP_011275255.1	membrane protein insertase YidC	-
SH_RS04475	947597..948913	+	1317	WP_011274424.1	ISL3 family transposase	-
SH_RS04480	948962..949603	-	642	WP_011275256.1	HD domain-containing protein	-
SH_RS04485	949703..951187	-	1485	WP_011275257.1	cardiolipin synthase	-
SH_RS04490	951374..951667	+	294	WP_011275258.1	copper-sensing transcriptional repressor CsoR	Antitoxin
SH_RS04495	951679..951885	+	207	WP_011275259.1	heavy-metal-associated domain-containing protein	Toxin
SH_RS13525	951993..952130	+	138	WP_011275260.1	hypothetical protein	-
SH_RS04500	952427..954121	+	1695	WP_011275261.1	IS1182 family transposase	-
SH_RS04505	954079..955278	-	1200	WP_011275262.1	rod shape-determining protein RodA	-
SH_RS04510	955696..956766	+	1071	WP_011275263.1	D-alanine--D-alanine ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	SCCmec	-	groEL / gnd	952510..1467007	514497
	-	inside	IScluster/Tn	-	-	947597..954121	6524

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Metal-sensitive transcriptional repressor (3-95)

Sequences

Toxin

Protein

• Length: 69 a.a.
• Molecular weight: 7857.79 Da
• Isoelectric Point: 4.0742

>T21201 WP_011275259.1 NC_007168:951679-951885 [Staphylococcus haemolyticus JCSC1435]
MNFSEIRISELNTEEQANSLQHRLEKMIGVDEVIVELNDQLVKISYETPTNLNSIEKEIYDDGYKVLG

Nucleotide

• Length: 207 bp

>T21201 NC_007168:951679-951885 [Staphylococcus haemolyticus JCSC1435]
ATGAACTTTAGTGAAATTAGAATTAGTGAATTAAATACTGAAGAGCAAGCTAATTCACTCCAACATAGACTTGAGAAGAT
GATAGGTGTAGATGAAGTAATTGTAGAACTAAATGACCAATTAGTTAAAATTTCTTATGAAACACCTACGAATTTAAATA
GTATTGAAAAAGAAATTTATGATGATGGTTATAAGGTATTAGGTTGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11222.83 Da
• Isoelectric Point: 6.6361

>AT21201 WP_011275258.1 NC_007168:951374-951667 [Staphylococcus haemolyticus JCSC1435]
MNNHENAHHSDQIKMNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMDKVNNGAQ
EEAMEELLVTFQKLMKD

Nucleotide

• Length: 294 bp

>AT21201 NC_007168:951374-951667 [Staphylococcus haemolyticus JCSC1435]
TTGAATAATCATGAAAATGCACATCATTCCGATCAAATTAAAATGAATTTAAAATCAAGACTTAATCGTATTGAAGGGCA
AGTTAGAGCGATTAATCGCATGATTGAAGAAGATGTATACTGTGATGACGTGCTAACTCAAATTAGAGCTACAAGATCAG
CTTTAAATAGTGTGGCCACTAAGTTGCTAGATCATCATATGAAAAGCTGTATCATGGATAAAGTGAATAACGGCGCTCAA
GAAGAAGCGATGGAAGAATTGTTAGTGACTTTTCAAAAATTAATGAAAGATTAG

Structures

Toxin

• AlphaFold DB: A0A2A1K7I8