Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 832898..833559 Replicon plasmid pMspAR02c
Accession NZ_CP080530
Organism Mesorhizobium sp. AR02

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag DBIPINDM_RS03885 Protein ID WP_258580821.1
Coordinates 832898..833335 (-) Length 146 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag DBIPINDM_RS03890 Protein ID WP_258580822.1
Coordinates 833332..833559 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DBIPINDM_RS03860 (DBIPINDM_007929) 828051..828734 - 684 WP_258580817.1 hypothetical protein -
DBIPINDM_RS03865 (DBIPINDM_007930) 829995..831338 - 1344 WP_258580818.1 IS1380 family transposase -
DBIPINDM_RS03870 831665..831914 + 250 Protein_774 type IV secretory system conjugative DNA transfer family protein -
DBIPINDM_RS03875 (DBIPINDM_007931) 832218..832463 + 246 WP_258580819.1 WGR domain-containing protein -
DBIPINDM_RS03880 (DBIPINDM_007932) 832640..832861 + 222 WP_258580820.1 HU family DNA-binding protein -
DBIPINDM_RS03885 (DBIPINDM_007933) 832898..833335 - 438 WP_258580821.1 PIN domain-containing protein Toxin
DBIPINDM_RS03890 (DBIPINDM_007934) 833332..833559 - 228 WP_258580822.1 CopG family transcriptional regulator Antitoxin
DBIPINDM_RS03895 (DBIPINDM_007935) 833838..834144 - 307 Protein_779 DUF736 domain-containing protein -
DBIPINDM_RS03900 (DBIPINDM_007936) 834786..835077 - 292 Protein_780 type II toxin-antitoxin system RelE/ParE family toxin -
DBIPINDM_RS03905 (DBIPINDM_007937) 835074..835382 - 309 WP_183455093.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
DBIPINDM_RS03910 (DBIPINDM_007938) 835565..835783 + 219 WP_258580823.1 integrase -
DBIPINDM_RS03915 (DBIPINDM_007939) 836074..836944 - 871 Protein_783 zincin-like metallopeptidase domain-containing protein -
DBIPINDM_RS03920 (DBIPINDM_007940) 837074..837628 - 555 Protein_784 ArdC-like ssDNA-binding domain-containing protein -
DBIPINDM_RS03925 (DBIPINDM_007941) 837970..838557 - 588 WP_258580824.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - groEL 1..988422 988422
- flank IS/Tn - - 829995..831338 1343


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(2-129)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15230.33 Da        Isoelectric Point: 6.7524

>T212009 WP_258580821.1 NZ_CP080530:c833335-832898 [Mesorhizobium sp. AR02]
VTFLLDVNVLIALIDPGHVAHDDAYGWFEVTGHAAWATCPITENGVLRIVGNQKYPNSPGSPAVVAQIVTKLRALQGHSF
WPDDVSLVGSGDIDAAKILTSAQVTDTYLLALAKAHGGQLASFDRKLSAAAVKSGKSSLHLITTS

Download         Length: 438 bp

>T212009 NZ_CP106906:c5074071-5073154 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGTGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8216.39 Da        Isoelectric Point: 6.2820

>AT212009 WP_258580822.1 NZ_CP080530:c833559-833332 [Mesorhizobium sp. AR02]
MRTTLAIDDDVLVAAKAMARQQDRSVGEIITDLARRSLRRPQAGSERNGIPLLSPRPDAPPVTLETVNALRDELP

Download         Length: 228 bp

>AT212009 NZ_CP106906:c5074835-5074077 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGTCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References