212008

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 709496..710097 Replicon plasmid pMspAR02c
Accession NZ_CP080530
Organism Mesorhizobium sp. AR02

Toxin (Protein)


Gene name tad Uniprot ID -
Locus tag DBIPINDM_RS03265 Protein ID WP_258580738.1
Coordinates 709774..710097 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID -
Locus tag DBIPINDM_RS03260 Protein ID WP_006205593.1
Coordinates 709496..709777 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DBIPINDM_RS03235 (DBIPINDM_007809) 704591..704878 - 288 WP_123170490.1 WGR domain-containing protein -
DBIPINDM_RS03240 (DBIPINDM_007810) 705093..705434 - 342 WP_258580734.1 hypothetical protein -
DBIPINDM_RS03245 (DBIPINDM_007811) 705431..706123 - 693 WP_258580735.1 ParA family protein -
DBIPINDM_RS03250 (DBIPINDM_007812) 706452..706862 + 411 WP_258580736.1 hypothetical protein -
DBIPINDM_RS03255 (DBIPINDM_007813) 706859..709363 + 2505 WP_258580737.1 relaxase/mobilization nuclease domain-containing protein -
DBIPINDM_RS03260 (DBIPINDM_007814) 709496..709777 - 282 WP_006205593.1 XRE family transcriptional regulator Antitoxin
DBIPINDM_RS03265 (DBIPINDM_007815) 709774..710097 - 324 WP_258580738.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DBIPINDM_RS03270 (DBIPINDM_007816) 710318..712558 - 2241 WP_258580739.1 type IV secretory system conjugative DNA transfer family protein -
DBIPINDM_RS03275 (DBIPINDM_007817) 712623..713669 - 1047 WP_258580740.1 P-type DNA transfer ATPase VirB11 -
DBIPINDM_RS03280 (DBIPINDM_007818) 713635..714969 - 1335 WP_258580741.1 type IV secretion system protein VirB10 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - groEL 1..988422 988422


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-101)

Antitoxin

HigA2-like, helix-turn-helix domain

(14-90)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12288.14 Da        Isoelectric Point: 10.3916

>T212008 WP_258580738.1 NZ_CP080530:c710097-709774 [Mesorhizobium sp. AR02]
MKVIEWLGSSRANVRAFPDDARIEAGWQLELVQRGDDPDDWKPMQIVGAGVREIRVREASGAFRVIYLATLEDRVLVLHA
FQKKTQATSKKDLDLAAQRLKRWKAER

Download         Length: 324 bp

>T212008 NZ_CP106906:c4917254-4916970 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10483.08 Da        Isoelectric Point: 7.0148

>AT212008 WP_006205593.1 NZ_CP080530:c709777-709496 [Mesorhizobium sp. AR02]
MNVEIYENVWDALADTEQEAANLKARSALLYEIRKAVQRWGIPQEEAAKRLGLTRPRINDLLRGKLAKFSLDALVNIAAS
AHLDIEIRVKEVA

Download         Length: 282 bp

>AT212008 NZ_CP106906:c4917486-4917244 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References