Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 310643..311286 Replicon plasmid pMspAR02c
Accession NZ_CP080530
Organism Mesorhizobium sp. AR02

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag DBIPINDM_RS01340 Protein ID WP_258581088.1
Coordinates 310643..311029 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag DBIPINDM_RS01345 Protein ID WP_258581089.1
Coordinates 311029..311286 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DBIPINDM_RS01320 (DBIPINDM_007439) 306524..307489 + 966 WP_258581084.1 plasmid partitioning protein RepB -
DBIPINDM_RS01325 (DBIPINDM_007440) 307645..308850 + 1206 WP_258581085.1 plasmid replication protein RepC -
DBIPINDM_RS01330 (DBIPINDM_007441) 309122..309469 + 348 WP_258581086.1 helix-turn-helix domain-containing protein -
DBIPINDM_RS01335 (DBIPINDM_007442) 309501..310640 - 1140 WP_258581087.1 site-specific integrase -
DBIPINDM_RS01340 (DBIPINDM_007443) 310643..311029 - 387 WP_258581088.1 type II toxin-antitoxin system VapC family toxin Toxin
DBIPINDM_RS01345 (DBIPINDM_007444) 311029..311286 - 258 WP_258581089.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
DBIPINDM_RS01350 (DBIPINDM_007445) 311455..312477 + 1023 WP_258581240.1 DUF1403 family protein -
DBIPINDM_RS01355 (DBIPINDM_007446) 312483..313205 + 723 WP_258581090.1 SMC-Scp complex subunit ScpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - groEL 1..988422 988422


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(2-84)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 13983.14 Da        Isoelectric Point: 4.7105

>T212007 WP_258581088.1 NZ_CP080530:c311029-310643 [Mesorhizobium sp. AR02]
MVIDTSAIVAILRSEPEAARLEQALVSDPIRLVPATCVLEARMVLVSRRGEHALAEIDLWLHKIGANIIPVDSELVDLAT
QAWLSYGKGRHPAALNFADCFSYALAKRADEPLLFIGKDFSQTDIEAA

Download         Length: 387 bp

>T212007 NZ_CP106906:c4814210-4813677 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9585.79 Da        Isoelectric Point: 6.7276

>AT212007 WP_258581089.1 NZ_CP080530:c311286-311029 [Mesorhizobium sp. AR02]
VSLNIKNPATVALADELARRQGISKTAAIHQALSERLHRMGFGDTAQERLLAELRSIRERLARLPERDNRTDEEIIGYDE
HGIPN

Download         Length: 258 bp

>AT212007 NZ_CP106906:c4814487-4814221 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References