Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 426835..427430 Replicon plasmid pMspAR07d
Accession NZ_CP080528
Organism Mesorhizobium sp. AR07

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag BPNPMPFG_RS38225 Protein ID WP_183455110.1
Coordinates 427242..427430 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag BPNPMPFG_RS38220 Protein ID WP_258598960.1
Coordinates 426835..427236 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BPNPMPFG_RS38200 (BPNPMPFG_006888) 421983..422414 - 432 WP_258598956.1 hypothetical protein -
BPNPMPFG_RS38205 (BPNPMPFG_006889) 422411..423112 - 702 WP_258598957.1 ParA family protein -
BPNPMPFG_RS38210 (BPNPMPFG_006890) 423755..424084 + 330 WP_244662163.1 hypothetical protein -
BPNPMPFG_RS38215 (BPNPMPFG_006891) 424081..426408 + 2328 WP_258598959.1 relaxase/mobilization nuclease domain-containing protein -
BPNPMPFG_RS38220 (BPNPMPFG_006892) 426835..427236 - 402 WP_258598960.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
BPNPMPFG_RS38225 (BPNPMPFG_006893) 427242..427430 - 189 WP_183455110.1 type II toxin-antitoxin system HicA family toxin Toxin
BPNPMPFG_RS38230 (BPNPMPFG_006894) 428363..429292 + 930 WP_258598961.1 ketoreductase domain-containing protein -
BPNPMPFG_RS38235 (BPNPMPFG_006895) 429289..430620 + 1332 WP_258598963.1 UDP-glucose/GDP-mannose dehydrogenase family protein -
BPNPMPFG_RS38240 (BPNPMPFG_006896) 430662..431741 + 1080 WP_258598964.1 glycosyltransferase -
BPNPMPFG_RS38245 (BPNPMPFG_006897) 431908..432072 - 165 WP_258598966.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - kdsA / gmd 1..1021442 1021442


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-123)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 6975.10 Da        Isoelectric Point: 11.1468

>T212005 WP_183455110.1 NZ_CP080528:c427430-427242 [Mesorhizobium sp. AR07]
MKSAAVIQALEADGWYEVARKGSHAQFKHEKKPGRVTVPHPKRDIPLGTLRSIERQSGLKLR

Download         Length: 189 bp

>T212005 NZ_CP106906:c2742507-2741185 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCTGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14292.08 Da        Isoelectric Point: 4.2543

>AT212005 WP_258598960.1 NZ_CP080528:c427236-426835 [Mesorhizobium sp. AR07]
MKQYIGLIHKDAESDFGVSFPDFPGVVTAGTDLDDARAMAEEALAFHIEGLAEDGEAIPEPSSLENVMADAENRRGVAIL
VAVKTEAKKAVRVNVTLPEDVLNRIDAFAEAHGYTRSGFIAQATQKVMEMEAA

Download         Length: 402 bp

>AT212005 NZ_CP106906:c2742773-2742507 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References