Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 386142..387619 Replicon plasmid pMspAR07d
Accession NZ_CP080528
Organism Mesorhizobium sp. AR07

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag BPNPMPFG_RS37980 Protein ID WP_258598930.1
Coordinates 386366..387619 (+) Length 418 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag BPNPMPFG_RS37975 Protein ID WP_258598928.1
Coordinates 386142..386369 (+) Length 76 a.a.

Genomic Context

BPNPMPFG_RS37945BPNPMPFG_RS37955BPNPMPFG_RS37960BPNPMPFG_RS37965BPNPMPFG_RS37970BPNPMPFG_RS37975BPNPMPFG_RS37980BPNPMPFG_RS37985BPNPMPFG_RS37950BPNPMPFG_RS37990BPNPMPFG_RS37995BPNPMPFG_RS38000BPNPMPFG_RS38005BPNPMPFG_RS38010BPNPMPFG_RS38015
Location: 381447..381692 (246 bp)
Type: Others
Protein ID: WP_258598922.1
Location: 382109..382543 (435 bp)
Type: Others
Protein ID: Protein_364
Location: 382727..384211 (1485 bp)
Type: Others
Protein ID: WP_258599098.1
Location: 384346..385485 (1140 bp)
Type: Others
Protein ID: WP_258598926.1
Location: 385371..385760 (390 bp)
Type: Others
Protein ID: WP_258599099.1
Location: 386142..386369 (228 bp)
Type: Antitoxin
Protein ID: WP_258598928.1
Location: 386366..387619 (1254 bp)
Type: Toxin
Protein ID: WP_258598930.1
Location: 387885..388046 (162 bp)
Type: Others
Protein ID: Protein_370
Location: 381897..382058 (162 bp)
Type: Others
Protein ID: WP_258598924.1
Location: 388138..388281 (144 bp)
Type: Others
Protein ID: WP_258598931.1
Location: 388531..389037 (507 bp)
Type: Others
Protein ID: Protein_372
Location: 389089..389442 (354 bp)
Type: Others
Protein ID: WP_258598933.1
Location: 389739..390833 (1095 bp)
Type: Others
Protein ID: WP_258598934.1
Location: 391147..391260 (114 bp)
Type: Others
Protein ID: Protein_375
Location: 392068..392564 (497 bp)
Type: Others
Protein ID: Protein_376
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BPNPMPFG_RS37945 (BPNPMPFG_006838)381447..381692+246WP_258598922.1transposase-
BPNPMPFG_RS37950381897..382058-162WP_258598924.1hypothetical protein-
BPNPMPFG_RS37955 (BPNPMPFG_006840)382109..382543+435Protein_364transposase-
BPNPMPFG_RS37960 (BPNPMPFG_006841)382727..384211+1485WP_258599098.1ISL3 family transposase-
BPNPMPFG_RS37965384346..385485+1140WP_258598926.1helix-turn-helix domain-containing protein-
BPNPMPFG_RS37970385371..385760+390WP_258599099.1transposase-
BPNPMPFG_RS37975 (BPNPMPFG_006843)386142..386369+228WP_258598928.1helix-turn-helix domain-containing proteinAntitoxin
BPNPMPFG_RS37980 (BPNPMPFG_006844)386366..387619+1254WP_258598930.1type II toxin-antitoxin system HipA family toxinToxin
BPNPMPFG_RS37985 (BPNPMPFG_006845)387885..388046+162Protein_370IS110 family transposase-
BPNPMPFG_RS37990 (BPNPMPFG_006846)388138..388281-144WP_258598931.1hypothetical protein-
BPNPMPFG_RS37995 (BPNPMPFG_006847)388531..389037-507Protein_372transposase-
BPNPMPFG_RS38000 (BPNPMPFG_006848)389089..389442-354WP_258598933.1hypothetical protein-
BPNPMPFG_RS38005 (BPNPMPFG_006849)389739..390833-1095WP_258598934.1response regulator-
BPNPMPFG_RS38010 (BPNPMPFG_006850)391147..391260-114Protein_375transposase-
BPNPMPFG_RS38015 (BPNPMPFG_006851)392068..392564-497Protein_376peptide deformylase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid-kdsA / gmd1..10214421021442
-flankIS/Tn--388447..389037590


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(145-350)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-63)


Sequences

Toxin        


Download         Length: 418 a.a.        Molecular weight: 45265.95 Da        Isoelectric Point: 6.2497

>T212002 WP_258598930.1 NZ_CP080528:386366-387619 [Mesorhizobium sp. AR07]
MTHLLDVYFRETKAGILSQDEDGALGYAYYADYLAGQQPRVISFSMPLREEPYADRVARPFFSGLLPDEGARQRLAGALG
LSAGNAFGLLKVIGGECAGALSLYPAGEAPAPSDDDEALSAERLKEIIGKLRERPLLGGEEGVRLSLAGAQDKLAVIVEG
ETIGLAKGGRPTTHILKPVIQALEGTVENELFCLRLAERLQLPVPRVEMRRAGDTAFLLIQRYDRARTDGGHIERLHQED
FCQALSVPPELKYEEEGGPGTKSSLDLIDRACARPAADRLRFIRMLIFHYLLGNADAHGKNYALLYDGDTPNLAPLYDVV
CTAAYPRLAKKLAMAIGGRSVPDTIQLKHWLTLVPETRGAQRLLIRDIATMAGRIGDEADALLAQLANVGADHAILKSVR
AVIATRATHLLRMTEGG

Download         Length: 1254 bp

>T212002 NZ_CP106906:742796-743281 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGCCCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8117.30 Da        Isoelectric Point: 11.3766

>AT212002 WP_258598928.1 NZ_CP080528:386142-386369 [Mesorhizobium sp. AR07]
MQTITDSKTLGLRIRQERKSQGLTQEQLAGLTGVGVRFVRELEGGKETCQLGRALQVASALGLFLSVGRRRDSGS

Download         Length: 228 bp

>AT212002 NZ_CP106906:742506-742799 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
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Antitoxin

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Source
ID
Structure
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References