Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 48045..48646 Replicon plasmid pMspAR07b
Accession NZ_CP080527
Organism Mesorhizobium sp. AR07

Toxin (Protein)


Gene name tad Uniprot ID A0A6M7Y451
Locus tag BPNPMPFG_RS34665 Protein ID WP_027054595.1
Coordinates 48323..48646 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID -
Locus tag BPNPMPFG_RS34660 Protein ID WP_006205593.1
Coordinates 48045..48326 (-) Length 94 a.a.

Genomic Context

BPNPMPFG_RS34645BPNPMPFG_RS34650BPNPMPFG_RS34655BPNPMPFG_RS34630BPNPMPFG_RS34635BPNPMPFG_RS34640BPNPMPFG_RS34660BPNPMPFG_RS34665BPNPMPFG_RS34670BPNPMPFG_RS34675BPNPMPFG_RS34680
Location: 44802..45116 (315 bp)
Type: Others
Protein ID: WP_258598231.1
Location: 45235..45645 (411 bp)
Type: Others
Protein ID: WP_258598026.1
Location: 45642..47912 (2271 bp)
Type: Others
Protein ID: WP_258598027.1
Location: 43381..43668 (288 bp)
Type: Others
Protein ID: WP_258598023.1
Location: 43879..44220 (342 bp)
Type: Others
Protein ID: WP_258598024.1
Location: 44217..44909 (693 bp)
Type: Others
Protein ID: WP_258598025.1
Location: 48045..48326 (282 bp)
Type: Antitoxin
Protein ID: WP_006205593.1
Location: 48323..48646 (324 bp)
Type: Toxin
Protein ID: WP_027054595.1
Location: 48867..51194 (2328 bp)
Type: Others
Protein ID: WP_258598029.1
Location: 51172..52218 (1047 bp)
Type: Others
Protein ID: WP_095204880.1
Location: 52184..53413 (1230 bp)
Type: Others
Protein ID: WP_258598030.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BPNPMPFG_RS34630 (BPNPMPFG_007818)43381..43668-288WP_258598023.1WGR domain-containing protein-
BPNPMPFG_RS34635 (BPNPMPFG_007819)43879..44220-342WP_258598024.1hypothetical protein-
BPNPMPFG_RS34640 (BPNPMPFG_007820)44217..44909-693WP_258598025.1ParA family protein-
BPNPMPFG_RS34645 (BPNPMPFG_007821)44802..45116+315WP_258598231.1hypothetical protein-
BPNPMPFG_RS34650 (BPNPMPFG_007822)45235..45645+411WP_258598026.1hypothetical protein-
BPNPMPFG_RS34655 (BPNPMPFG_007823)45642..47912+2271WP_258598027.1relaxase/mobilization nuclease domain-containing protein-
BPNPMPFG_RS34660 (BPNPMPFG_007824)48045..48326-282WP_006205593.1XRE family transcriptional regulatorAntitoxin
BPNPMPFG_RS34665 (BPNPMPFG_007825)48323..48646-324WP_027054595.1type II toxin-antitoxin system RelE/ParE family toxinToxin
BPNPMPFG_RS34670 (BPNPMPFG_007826)48867..51194-2328WP_258598029.1type IV secretory system conjugative DNA transfer family protein-
BPNPMPFG_RS34675 (BPNPMPFG_007827)51172..52218-1047WP_095204880.1P-type DNA transfer ATPase VirB11-
BPNPMPFG_RS34680 (BPNPMPFG_007828)52184..53413-1230WP_258598030.1type IV secretion system protein VirB10-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..348101348101


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-101)

Antitoxin

HigA2-like, helix-turn-helix domain

(14-90)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12289.12 Da        Isoelectric Point: 10.1375

>T212001 WP_027054595.1 NZ_CP080527:c48646-48323 [Mesorhizobium sp. AR07]
MKVIEWLGSSRADVRAFPDDARIEAGWQLELVQRGDDPDDWKPMQIVGAGVREIRVREASGAFRVIYLATLEDRVLVLHA
FQKKTQATSKKDLDLAAQRLKRWKAER

Download         Length: 324 bp

>T212001 NZ_CP106906:355278-355625 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTGTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGTGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10483.08 Da        Isoelectric Point: 7.0148

>AT212001 WP_006205593.1 NZ_CP080527:c48326-48045 [Mesorhizobium sp. AR07]
MNVEIYENVWDALADTEQEAANLKARSALLYEIRKAVQRWGIPQEEAAKRLGLTRPRINDLLRGKLAKFSLDALVNIAAS
AHLDIEIRVKEVA

Download         Length: 282 bp

>AT212001 NZ_CP106906:355625-355924 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A6M7Y451

Antitoxin

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Source
ID
Structure
No matching records found

References